Evidence map›Paper›PMID 40661379›Full record

ArticlebioRxiv : the preprint server for biology2025

Treatment Resistant Persister Cells Exploit Macrophage Lipid Metabolism to Sustain Glioblastoma Growth.

Avirup Chakraborty, Changlin Yang, Aryeh Silver, Diana Feier, Guimei Tian, Avinash Pittu, Christina Von Roemeling, Nagheme Thomas, Michael Andrews, Cole Conforti and 10 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Avirup Chakraborty
Changlin Yang
Aryeh Silver
Diana Feier
Guimei Tian
Avinash Pittu
Christina Von Roemeling
Nagheme Thomas
Michael Andrews
Cole Conforti
Olusegun O Sobanjo
Nyla T Searl
Miruna N Anica
Raquel McTiernan
Maryam Rahman
Jianping Huang
Jeffrey K Harrison
Duane A Mitchell
Matthew Sarkisian
Loic P Deleyrolle

Funding

Metabolic interactions between tumor cells and the immune system in GBM: A potential Achilles heel of GBM for novel therapeuticsR01NS121075 · NINDS · UNIVERSITY OF FLORIDA · PI DELEYROLLE, LOIC PIERRE · 2022 to 2025
$1.6M
Slow cycling cell RNA based T cell therapy to prevent recurrence in GBMR21NS116578 · NINDS · UNIVERSITY OF FLORIDA · PI DELEYROLLE, LOIC PIERRE · 2021 to 2022
$419k
Optimizing CAR T therapy via metabolic engineering for thetreatment of GBMR21CA282979 · NCI · UNIVERSITY OF FLORIDA · PI DELEYROLLE, LOIC PIERRE · 2023 to 2024
$381k
NCI NIH HHS R21 CA282979NINDS NIH HHS R01 NS121075NINDS NIH HHS R21 NS116578
6 · The paper itself

Abstract

Glioblastoma (GBM) displays pronounced intratumoral heterogeneity, posing significant challenges to understanding its biology and developing effective treatments. Using spatial multi-omics,

Identifiers

PMID40661379
PMCPMC12259058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.