Evidence map›Paper›PMID 40661369›Full record

ArticlebioRxiv : the preprint server for biology2025

Rapid transcriptional response to a dynamic morphogen by time integration.

Susanna E Brantley, Jacqueline Janssen, Anna Chao, Massimo Vergassola, Shelby A Blythe, Stefano Di Talia

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Susanna E BrantleyDepartment of Cell Biology and Duke Center for Quantitative Living Systems, Duke University Medical Center, Durham 27705, United States.ORCID 0000-0002-2420-1275
Jacqueline JanssenDepartment of Physics, École Normale Supérieure, Paris 75005, France.
Anna ChaoDepartment of Cell Biology and Duke Center for Quantitative Living Systems, Duke University Medical Center, Durham 27705, United States.
Massimo VergassolaDepartment of Physics, École Normale Supérieure, Paris 75005, France.
Shelby A BlytheDepartment of Molecular Biosciences, Northwestern University, Evanston IL 60208, United States.
Stefano Di TaliaDepartment of Cell Biology and Duke Center for Quantitative Living Systems, Duke University Medical Center, Durham 27705, United States.ORCID 0000-0001-9758-7925

Funding

Mechanisms and developmental functions of cytoplasmic flows in early embryogenesisR01GM136763 · NIGMS · DUKE UNIVERSITY · PI DI TALIA, STEFANO · 2021 to 2023
$1.1M
Dissecting input-output relationships of Developmental BMP SignalingK99HD115781 · NICHD · DUKE UNIVERSITY · PI BRANTLEY, SUSANNA ELIZABETH · 2024 to 2025
$209k
Quantitative analysis of signaling dynamics across the BMP morphogen gradientF32GM145070 · NIGMS · DUKE UNIVERSITY · PI BRANTLEY, SUSANNA ELIZABETH · 2022 to 2023
$139k
NICHD NIH HHS K99 HD115781NIGMS NIH HHS F32 GM145070NIGMS NIH HHS R01 GM136763
6 · The paper itself

Abstract

During development, cells must interpret extracellular signals with speed and accuracy. While morphogen gradients pattern tissues, how cells respond to dynamic morphogens remains unclear. Here, we investigate how dorsal patterning in the

Identifiers

PMID40661369
PMCPMC12259056

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.