Evidence map›Paper›PMID 40661363›Full record

ArticlebioRxiv : the preprint server for biology2025

Multiplex Proteomics of Lewy Body Dementia Reveals Cerebrospinal Fluid Biomarkers of Disease Pathology and Progression.

Lenora Higginbotham, Anantharaman Shantaraman, Qi Guo, Edward J Fox, Pritha Bagchi, Fang Wu, James J Lah, Allan I Levey, Nicholas T Seyfried

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lenora HigginbothamCenter for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-8694-9211
Anantharaman ShantaramanCenter for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0003-1384-941X
Qi GuoCenter for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA.
Edward J FoxCenter for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA.
Pritha BagchiCenter for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0001-7229-9476
Fang WuCenter for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA.
James J LahCenter for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-8810-620X
Allan I LeveyCenter for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-3153-502X
Nicholas T SeyfriedCenter for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-4507-624X

Funding

Supplement to AMP-AD Brain Proteomic Network Enhancement, Validation and Translation into CSF BiomarkersU01AG061357 · NIA · EMORY UNIVERSITY · PI LEVEY, ALLAN I, SEYFRIED, NICHOLAS THOMAS · 2018 to 2022
$9.1M
Novel Protein Biomarkers of Corticolimbic Pathophysiology in Lewy body DementiaU01NS128433 · NINDS · EMORY UNIVERSITY · PI ALLAN I LEVEY, Nicholas Thomas Seyfried · 2022 to 2026
$6.7M
Identifying Pathophysiological Signatures of DLB Cognitive and Neuropsychiatric Decline Using a Systems-Based Proteomic ApproachK23NS119964 · NINDS · EMORY UNIVERSITY · PI Lenora Higginbotham · 2022 to 2026
$976k
Developing Biomarkers of Parkinson’s Disease Inflammation Using a Network Proteomics ApproachR21NS123882 · NINDS · EMORY UNIVERSITY · PI HIGGINBOTHAM, LENORA · 2021 to 2021
$430k
NIA NIH HHS U01 AG061357NINDS NIH HHS K23 NS119964NINDS NIH HHS R21 NS123882NINDS NIH HHS U01 NS128433
6 · The paper itself

Abstract

Lewy body dementia (LBD), which encompasses Parkinson's disease dementia (PDD) and Dementia with Lewy bodies (DLB), currently lacks established biofluid markers reflective of its complex molecular pathophysiology. Multiplex proteomic tools, such as the recently released NUcleic acid Linked ImmunoSandwich Assay (NULISA

Identifiers

PMID40661363
PMCPMC12259125

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.