Evidence map›Paper›PMID 40661354›Full record

ArticlebioRxiv : the preprint server for biology2025

Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis.

José Reyes, Isabella Del Priore, Andrea C Chaikovsky, Nikhita Pasnuri, Ahmed M Elhossiny, Tobias Krause, Andrew Moorman, Catherine Snopkowski, Meril Takizawa, Cassandra Burdziak and 13 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

José ReyesCancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-1133-4933
Isabella Del PrioreCancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Andrea C ChaikovskyCancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-1842-5384
Nikhita PasnuriComputational and Systems Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Ahmed M ElhossinyDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-0884-8754
Tobias KrauseSingle-cell Analytics Innovation Lab, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Andrew MoormanSingle-cell Analytics Innovation Lab, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Catherine SnopkowskiSingle-cell Analytics Innovation Lab, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Meril TakizawaSingle-cell Analytics Innovation Lab, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID 0009-0007-9621-6736
Cassandra BurdziakComputational and Systems Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-6008-7783
Nalin RatnayekeCancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-0620-8374
Ignas MasillioniSingle-cell Analytics Innovation Lab, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Yu-Jui HoCancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-7540-024X
Ronan ChalignéSingle-cell Analytics Innovation Lab, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Paul B RomesserDepartment of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-8268-2903
Aveline FilliolCancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Tal NawyComputational and Systems Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-3720-3699
John P MorrisCancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Zhen ZhaoCancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Marina Pasca Di MaglianoRogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-9632-9035
Direna Alonso-CurbeloCancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-6674-3059
Dana Pe'erComputational and Systems Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-9259-8817
Scott W LoweCancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-5284-9650

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
The Center for Tumor-Immune Systems Biology at MSKCCU54CA274492 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Dana Pe'er · 2022 to 2026
$16.3M
Tumor Microenvironment Crosstalk Drives Early Lesions in Pancreatic CancerU54CA274371 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Elana Fertig · 2022 to 2026
$9.5M
Fibroblast orchestration of the immune response in pancreatic cancerU01CA274154 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Howard C. Crawford, Timothy Louis Frankel · 2022 to 2026
$4.2M
Mechanisms of p53 Engagement and Action at the Benign-to-Malignant Transition in Sporadic TumorigenesisR01CA283378 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI SCOTT W. LOWE, Dana Pe'er · 2023 to 2026
$2.9M
Targeting the fibroblast-immune cell crosstalk to relieve immune suppression in the pancreatic cancer microenvironmentR01CA260752 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PASCA DI MAGLIANO, MARINA · 2022 to 2025
$2.8M
Dissecting the role of Notch signaling in the pancreatic cancer microenvironment.R01CA271510 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Filip Bednar, Marina Pasca Di Magliano · 2022 to 2026
$2.6M
Interrupting Cellular Crosstalk in the Immunosuppressive Microenvironment of Pancreas CancerU01CA224145 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CRAWFORD, HOWARD C., PASCA DI MAGLIANO, MARINA · 2017 to 2021
$2.6M
Mechanisms of myeloid cell driven pancreatic plasticity and carcinogenesisR01CA268426 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Timothy Louis Frankel, Marina Pasca Di Magliano · 2023 to 2026
$2.5M
Investigating the contribution of cellular senescence to the efficacy of radiation therapy.K08CA255574 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ROMESSER, PAUL BERNARD · 2021 to 2025
$1.2M
Establishment and regulation of the immune suppressive microenvironment in pancreatic cancerR01CA264843 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PASCA DI MAGLIANO, MARINA · 2022 to 2022
$492k
Investigating the Role of Cell Plasticity in Malignant TransformationK00CA245471 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CHAIKOVSKY, ANDREA CHRISTINE · 2022 to 2025
$389k
NCI NIH HHS K00 CA245471NCI NIH HHS K08 CA255574NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA260752NCI NIH HHS R01 CA264843NCI NIH HHS R01 CA268426NCI NIH HHS R01 CA271510NCI NIH HHS R01 CA283378NCI NIH HHS U01 CA224145NCI NIH HHS U01 CA274154NCI NIH HHS U54 CA274371NCI NIH HHS U54 CA274492
6 · The paper itself

Abstract

The transition from benign to malignant growth is a pivotal yet poorly understood step in cancer progression that marks the shift from a pathologically inert condition to a clinically lethal disease. Here, we integrate lineage tracing, single-cell and spatial transcriptomics to visualize the molecular, cellular and tissue-level events that promote or restrain malignancy during the tumor initiation in mouse models of pancreatic ductal adenocarcinoma (PDAC). We identify a discrete progenitor-like population of

Identifiers

PMID40661354
PMCPMC12259082

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.