Evidence map›Paper›PMID 40661347›Full record

ArticlebioRxiv : the preprint server for biology2025

An Anaerobic Pathogen Rewires Host Metabolism to Fuel Oxidative Growth in the Inflamed Gut.

Luisella Spiga, Ryan T Fansler, Alexandra Grote, Madison Langford-Butler, Asia K Miller, Maxwell Neal, Owen F Hale, Yifan Wu, Deepanshu Singla, M Wade Calcutt and 17 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Luisella Spiga
Ryan T Fansler
Madison Langford-Butler
Asia K Miller
Maxwell Neal
Owen F Hale
Yifan Wu
Deepanshu Singla
M Wade Calcutt
Abigail E Rose
Madeline M Bresson
Alexandra C Schrimpe-Rutledge
Brittany Berdy
Simona G Codreanu
Mary Kay Washington
Benjamin P Bratton
Stacy D Sherrod
John A McLean
Karsten Zengler
Cynthia L Sears
Megan G Behringer
Andreas Gnirke
Jonathan Livny
Danyvid Olivares-Villagómez
Ashlee M Earl

Funding

Commensal resilience mechanisms in the inflamed intestineR35GM147470 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Wenhan Zhu · 2022 to 2026
$2.2M
Commensal bacteria resilience mechanisms in the inflamed intestineR01DK134692 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Wenhan Zhu · 2023 to 2026
$1.4M
Iron homeostasis in sustaining commensal resilience in the inflamed gutF31AI178950 · NIAID · VANDERBILT UNIVERSITY · PI Ryan T Fansler · 2024 to 2026
$105k
NIAID NIH HHS F31 AI178950NIDDK NIH HHS R01 DK134692NIGMS NIH HHS R35 GM147470
6 · The paper itself

Abstract

To colonize their host and cause disease, enteric pathogens must deploy their virulence factors to establish distinct nutrient niches. How obligate anaerobic pathogens construct nutrient niches in the densely populated large intestine remains poorly understood. Enterotoxigenic

Identifiers

PMID40661347
PMCPMC12258715

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.