Evidence map›Paper›PMID 40661343›Full record

ArticlebioRxiv : the preprint server for biology2025

Immune cell type divergence in a basal chordate.

Tal D Scully, C J Pickett, Nicolas A Gort-Freitas, Bradley Davidson, Allon M Klein

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Redefinition of the toll-like receptor repertoire inFrontiers in cellular and infection microbiology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Tal D ScullyDept. of Systems Biology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2366-9343
C J PickettDept. of Biology, Swarthmore College, Swarthmore, PA, USA.ORCID 0000-0002-2326-5437
Nicolas A Gort-FreitasDept. of Systems Biology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8614-4782
Bradley DavidsonDept. of Biology, Swarthmore College, Swarthmore, PA, USA.ORCID 0000-0001-5082-7872
Allon M KleinDept. of Systems Biology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8913-7879

Funding

Micro-capsule technology for high-throughput analyses of cell-cell interactionsR01GM153805 · NIGMS · HARVARD MEDICAL SCHOOL · PI Allon Moshe Klein · 2024 to 2026
$1.1M
NIGMS NIH HHS R01 GM153805
6 · The paper itself

Abstract

Evolutionary adaptations often occur at the level of cell types and cellular function. Innate immune cells are a promising system for studying cell type evolution, as they are widespread across metazoans, have several conserved functions, and are under selective pressure from pathogens. However, molecular characterizations of invertebrate immune cells are limited, and it remains unclear whether invertebrate immune cell types are homologous to those in vertebrates. Here we use single-cell RNA sequencing,

Indexed as

basal chordatescell type evolutionCiona robustacross-species homologyevolution of hematopoietic hierarchyinnate immune cellsnon-vertebrate immune cellsorigins of immunityphagocytesvanadocytes

Identifiers

PMID40661343
PMCPMC12258801

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.