ArticlemedRxiv : the preprint server for health sciences2025
Exploring the Impact of Oral Health and Vaccination on Pneumonia-causing Bacteria: Insights from Predictive Modeling.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Nursing home acquired pneumonia (NHAP) is a leading cause of mortality in long-term care facilities (LTCFs). The primary mechanism of infection in older individuals is macro-aspiration of opportunistic pathogens colonizing the oral and nasal cavities. Pneumococcal vaccination is the primary preventative measure, but oral hygiene is increasingly explored as a strategy for reducing oral colonization. While promising, oral health interventions have shown mixed results, likely due to variation in the way that different NHAP-associated pathogens respond to these interventions. To test this, we analyzed oral health survey responses, pneumococcal vaccination status, and longitudinal colonization to identify factors linked to carriage of each pathogen. We found that oral hygiene impacted carriage of bacteria which more frequently colonized the oral cavity (
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