ArticleTranslational neuroscience2025
Mechanism study on the attenuation of cerebral ischemia-reperfusion injury by LBP extract through regulation of SIRT1/PGC-1α axis.
Article in Translational neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Bioactive spectrum of goji berries (Food chemistry: X · 2026Review
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9 authors.
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Abstract
Objective: This study aims to determine if Methods: A cellular hypoxia/reoxygenation model (OGD/R) using HT22 cells was established to simulate cerebral ischemia-reperfusion injury. Cells were allocated into four groups: normal (Control), hypoxia (OGD/R), LBP extract-treated (OGD/R + LBP at 25, 50, 100 μg/mL), and SIRT1-inhibited (OGD/R + S100). Western blot and qPCR were performed to detect the expression of pathway-related factors, oxidative stress, mitochondrial function, and apoptosis-related factors. Results: Compared to the Control group, the OGD/R group exhibited significantly reduced cell survival, increased LDH release, apoptosis rate, and reactive oxygen species (ROS) levels. After intervention with LBP extract, cell survival increased, LDH release, ROS levels, and apoptosis rates reduced. The above injuries were associated with the inhibition of the SIRT1/PGC-1α pathway. LBP extract can attenuate the hypoxia-reperfusion-induced inhibition of the SIRT1/PGC-1α pathway and reverse the resulting high levels of oxidative stress and apoptosis, ultimately ameliorating cellular injury. Conclusion: LBP extract's protective effects against ischemia-reperfusion injury in HT22 cells appear linked to the modulation of the SIRT1/PGC-1α pathway and a reduction in oxidative stress.
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