ArticleFrontiers in neurology2025
Unveiling the dual threat: combined elevated triglyceride-glucose index and intracranial arterial stenosis burden for enhanced stroke risk stratification.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The triglyceride-glucose index: updating evidence from clinical settings to molecular mechanisms in ageing-related cerebrovascular diseases.Cardiovascular diabetology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The relationship between an elevated triglyceride-glucose index (TyG) combined with intracranial arterial stenosis (ICAS) and stroke recurrence remains incompletely understood. This study investigated how varying ICAS burdens influence the prognosis of ischemic stroke patients with different TyG levels. Methods: This prospective cohort study analyzed a consecutively enrolled population of 712 acute ischemic stroke patients, with intracranial atherosclerotic burden quantitatively evaluated via computed tomography angiography (CTA) or three-dimensional time-of-flight magnetic resonance angiography (MRA), and stenosis severity graded according to WASID criteria. Participants were categorized into four mutually exclusive subgroups based on TyG index quartiles and ICAS status (presence/absence). To investigate exposure-response gradients, further stratification incorporated both ICAS severity (no/mild [<50%], moderate [50-69%], or severe [70-99% or occlusion] stenosis) and vascular involvement (single vs. multiple affected arterial territories). The primary endpoint was defined as ischemic stroke recurrence within a standardized 90-day follow-up period. Cox proportional hazards models examined adjusted associations between TyG/ICAS status and outcomes, complemented by Kaplan-Meier curves with log-rank tests for time-to-event visualization. Mechanistic pathways were delineated through causal mediation analysis employing Quasi-Bayesian approximation (100 Monte Carlo simulations) to quantify mediating effects between metabolic dysfunction and cerebrovascular outcomes. Conclusion: The synergistic combination of elevated TyG index and ICAS burden demonstrated superior prognostic value for 3-month stroke recurrence risk compared to either parameter independently, suggesting that concurrent assessment of insulin resistance (via TyG index) and vascular imaging biomarkers (via ICAS burden) may refine early risk stratification. This finding underscores the importance of integrating systemic metabolic dysfunction with structural cerebrovascular pathology to identify patients at heightened vulnerability during the critical post-stroke recovery window.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.