Evidence map›Paper›PMID 40661239›Full record

ArticleJournal of hepatocellular carcinoma2025

Multidisciplinary Team Management of Hepatocellular Carcinoma in the MENA Region: Current Practices, Challenges, and Gaps.

Mohamed El-Kassas, Rofida Khalifa, Khalid M AlNaamani, Hend Shousha, Yusuf Yilmaz, Faisal M Sanai, Maen Almattooq, Asma Labidi, Maisam W I Akroush, Nabil Debzi and 10 more

Abstract read
In one paragraph

Article in Journal of hepatocellular carcinoma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Mohamed El-KassasEndemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt.
Rofida KhalifaTropical Medicine Department, Faculty of Medicine, Minia University, Minya, Egypt.ORCID 0000-0002-5867-0715
Khalid M AlNaamaniSteatotic Liver Diseases Study Foundation in Middle East and North Africa (SLMENA), Cairo, Egypt.
Hend ShoushaEndemic Medicine and Hepato-Gastroenterology Department, Cairo University, Cairo, Egypt.
Yusuf YilmazSteatotic Liver Diseases Study Foundation in Middle East and North Africa (SLMENA), Cairo, Egypt.ORCID 0000-0003-4518-5283
Faisal M SanaiSteatotic Liver Diseases Study Foundation in Middle East and North Africa (SLMENA), Cairo, Egypt.
Maen AlmattooqSteatotic Liver Diseases Study Foundation in Middle East and North Africa (SLMENA), Cairo, Egypt.ORCID 0009-0008-9759-1893
Asma LabidiSteatotic Liver Diseases Study Foundation in Middle East and North Africa (SLMENA), Cairo, Egypt.
Maisam W I AkroushSteatotic Liver Diseases Study Foundation in Middle East and North Africa (SLMENA), Cairo, Egypt.
Nabil DebziSteatotic Liver Diseases Study Foundation in Middle East and North Africa (SLMENA), Cairo, Egypt.
Mohamed Omar AbdelmalekTropical Medicine and Gastroenterology Department, Assiut University, Assiut, Egypt.
Nermeen Sherif AbdeenTropical Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Ali TumiSteatotic Liver Diseases Study Foundation in Middle East and North Africa (SLMENA), Cairo, Egypt.
Mohamed ElbadryEndemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt.
Amr El FoulyEndemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt.
Eman MarwanEndemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt.
Jassim Al SuwaidiScientific, Academic, and Faculty Affairs, Hamad Medical Corporation, Doha, Qatar.
Abdel-Naser ElzoukiSteatotic Liver Diseases Study Foundation in Middle East and North Africa (SLMENA), Cairo, Egypt.ORCID 0000-0002-9132-1752
Khalid A AlswatSteatotic Liver Diseases Study Foundation in Middle East and North Africa (SLMENA), Cairo, Egypt.ORCID 0000-0002-3521-8523
Steatotic Liver Disease Study Foundation in Middle East and North Africa (SLMENA) Collaborators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with a high disease burden in the Middle East and North Africa (MENA) region. Multidisciplinary teams (MDTs) are essential for optimizing HCC management; however, their implementation and impact may vary across healthcare settings. This study evaluates the structure, decision-making processes, and challenges faced by MDTs in HCC treatment centers across the MENA region. Patients and Methods: This cross-sectional, multicenter study surveyed representatives from 53 HCC treatment centers across 38 cities in 11 MENA countries. A structured questionnaire was electronically distributed to assess MDT composition, meeting frequency, decision-making processes, adherence to clinical guidelines, patient management pathways, and challenges in HCC treatment. Results: Among the surveyed centers, 84.9% (n=45) reported having an established MDT. The most common specialties involved in MDT composition were hepatology (100%), interventional radiology (97.8%), medical oncology (91.1%), and hepatobiliary surgery (80%). Barcelona Clinic Liver Cancer staging was used in 95.6% of centers. Despite acknowledging MDT benefits, major challenges were documented by participants, including resource limitations (13.2%), financial constraints (13.2%), patient nonadherence (9.4%), and limited access to advanced technology (11.3%). Telemedicine was underutilized (9.4% of centers), and only 15.1% experienced participation in clinical trials. Conclusion: Our result highlights the pivotal role of MDTs in HCC management in the MENA region, demonstrating adherence to evidence-based guidelines and exposing critical gaps in resource availability, technology integration, and patient-centered decision-making. Strengthening MDTs through enhanced resource allocation, digital health adoption, and increased clinical trial participation is essential to improving HCC outcomes in the region.

Indexed as

cancer managementclinical decision-makinghepatocellular carcinomaMENA regionmultidisciplinary team

Identifiers

PMID40661239
PMCPMC12256939

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.