Evidence map›Paper›PMID 40661223›Full record

ArticleJournal of crystal growth2022

The pathway from the solution to the steps.

Peter G Vekilov, Lakshmanji Verma, Jeremy C Palmer, Rajshree Chakrabarti, Monika Warzecha

Abstract read
In one paragraph

Article in Journal of crystal growth, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Direct observation of cholesterol monohydrate crystallization.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. The elementary reactions for incorporation into crystals.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Peter G VekilovWilliam A. Brookshire Department of Chemical and Biomolecular Engineering, University of Houston, 4226 Martin Luther King Boulevard, Houston, TX 77204-4004, USA.
Lakshmanji VermaWilliam A. Brookshire Department of Chemical and Biomolecular Engineering, University of Houston, 4226 Martin Luther King Boulevard, Houston, TX 77204-4004, USA.
Jeremy C PalmerWilliam A. Brookshire Department of Chemical and Biomolecular Engineering, University of Houston, 4226 Martin Luther King Boulevard, Houston, TX 77204-4004, USA.
Rajshree ChakrabartiWilliam A. Brookshire Department of Chemical and Biomolecular Engineering, University of Houston, 4226 Martin Luther King Boulevard, Houston, TX 77204-4004, USA.
Monika WarzechaEPSRC CMAC Future Manufacturing Research Hub, c/o Strathclyde Institute of Pharmacy and Biomedical Sciences, Technology and Innovation Centre, 99 George Street, Glasgow G1 1RD, U.K.

Funding

Dual artemisinin action combats resistanceR01AI150763 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SULLIVAN, DAVID JOSEPH, VEKILOV, PETER G · 2021 to 2025
$2.9M
Hematin crystallization in Plasmodium parasitesR21AI126215 · NIAID · UNIVERSITY OF HOUSTON · PI VEKILOV, PETER G · 2016 to 2017
$383k
NIAID NIH HHS R01 AI150763NIAID NIH HHS R21 AI126215
6 · The paper itself

Abstract

The pathway of solute access to the kinks is an issue of unparalleled fundamental significance that also carries severe consequences for the morphologies, quality, and, utility of the grown crystals. Here we review experimental tests to distinguish between the two pathways of solute supply to the steps: directly from the solution or after first adsorbing on the terraces between steps and diffusing along the crystal surface towards the steps. Generalizing the evidence accumulated with ionic, organic, protein, and biomineral crystals to-date, we put forth a criterion to predict the pathway of solute supply to the kinks. The proposed criterion relies on the interactions of the solvent with solute and the crystal surface. Solvents that strongly associate to the crystal surfaces and solute molecules weaken solute adsorption and contribute to faster surface diffusion and abundant solute supply to the steps, which, in turn, makes the surface diffusion pathway faster than the one directly from the solution. Solvents that do not attenuate the solute-crystal surface attraction promote strong adsorption, which suppresses surface diffusion and encourages direct incorporation into the kinks. We propose that computational methods to predict

Indexed as

A1. Organic solventA1. Solution growthA1. Surface diffusionB1. Aqueous solutionB1. Direct incorporationB1. Mechanisms

Identifiers

PMID40661223
PMCPMC12258150

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.