Evidence map›Paper›PMID 40661202›Full record

ArticleRSC advances2025

Design, synthesis and anticancer evaluation of novel hydrazide-2-oxindole analogues as GSK-3β kinase inhibitors.

Ashok Madarakhandi, Sujeet Kumar, Nishith Teraiya, Dominique Schols, Soujanya J Vastrad, P Shyamjith, Bibha Choudhary, Arzoo Rai, Subhas S Karki

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ashok MadarakhandiDepartment of Pharmaceutical Chemistry, Dr Prabhakar B. Kore Basic Science Research Center, Off-Campus, KLE College of Pharmacy Bengaluru-560010 India subhasskarki@gmail.com subhashkarki@klepharmblr.org +91 8023425373 +91 80 23325611.ORCID https://orcid.org/0009-0008-5940-6976
Sujeet KumarDepartment of Pharmaceutical Chemistry, Nitte College of Pharmaceutical Sciences (Nitte-Deemed to be University, Mangaluru) Yelahanka Bengaluru Karnataka 560064 India.ORCID https://orcid.org/0000-0002-0833-158X
Nishith TeraiyaDepartment of Pharmaceutical Chemistry, K. B. Institute of Pharmaceutical Education and Research, Kadi Sarva Vishvavidyalaya Gandhinagar 382023 Gujarat India.ORCID https://orcid.org/0000-0003-1301-915X
Dominique ScholsRega Institute for Medical Research, Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, KU Leuven B-3000 Leuven Belgium.ORCID https://orcid.org/0000-0003-3256-5850
Soujanya J VastradDepartment of Pharmacy Practice, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences Bengaluru 560054 Karnataka India.ORCID https://orcid.org/0009-0008-4890-0266
P ShyamjithInstitute of Bioinformatics and Biotechnology Electronic City Phase 1 Bengaluru India.ORCID https://orcid.org/0009-0004-9646-763X
Bibha ChoudharyInstitute of Bioinformatics and Biotechnology Electronic City Phase 1 Bengaluru India.ORCID https://orcid.org/0000-0001-7173-0682
Arzoo RaiSchool of Applied Material Science, Central University of Gujarat Gandhinagar 382030 Gujarat India.
Subhas S KarkiDepartment of Pharmaceutical Chemistry, Dr Prabhakar B. Kore Basic Science Research Center, Off-Campus, KLE College of Pharmacy Bengaluru-560010 India subhasskarki@gmail.com subhashkarki@klepharmblr.org +91 8023425373 +91 80 23325611.ORCID https://orcid.org/0000-0002-5599-3594

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GSK-3β plays an essential role in cancer progression, making it a promising target for therapeutic intervention with glycogen synthase kinase (GSK-3β) inhibitors. The designed compounds were discovered for their potential role against the proliferation of cancer

Identifiers

PMID40661202
PMCPMC12257299

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.