ArticleJournal of inflammation research2025
The Relationship of Insulin Resistance and Systemic Inflammation with Cardiovascular Outcomes in Non-Diabetic Patients Undergoing Coronary Artery Bypass Grafting.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- The Effect of Preoperative Oral Carbohydrate Loading on Insulin Resistance in Adult Patients Undergoing On-Pump Cardiac Surgery: A Randomized Controlled Trial.Annals of cardiac anaesthesia · 2026Trial
- Predicting Stroke Incidence Using Estimated Glucose Disposal Rate Index in the Population with Cardiovascular-Kidney-Metabolic Syndrome Stage 0-3 in the Chinese Middle-Aged and Elderly Population.Cardiorenal medicine · 2026Observational
- Associations between novel triglyceride-glucose-related indices and the incidence of hypertension among Chinese middle-aged and elderly adults: a nationwide prospective cohort study.Cardiovascular diabetology. Endocrinology reports · 2025Article
- Diagnostic Performance of Surrogate Indices of Insulin Resistance Compared with HOMA2-IR in Non-Diabetic Patients with Acute Coronary Syndrome.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
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Abstract
Background: Insulin resistance (IR) is linked to adverse cardiovascular outcomes, but its mechanisms are not fully understood. This study investigates the relationship between IR and systemic inflammation and evaluates how systemic inflammation affects the correlation between IR and prognosis in non-diabetic patients undergoing coronary artery bypass grafting (CABG). Methods: This study enrolled 1,658 patients post-CABG. IR was assessed via the estimated glucose disposal rate (eGDR), and systemic inflammation was measured by C-reactive protein (CRP) levels. The correlation between eGDR and CRP was analyzed using linear regression. Associations of eGDR and CRP with major adverse cardiovascular and cerebrovascular events (MACCEs) were evaluated through the Kaplan-Meier method, restricted cubic splines (RCS), and adjusted Cox regression analyses. A novel two-stage regression method for survival data was used in the mediation analysis. Results: Over a median follow-up period of 60.9 months, 414 MACCEs cases were documented. The RCS analysis revealed an L-shaped association between eGDR and MACCEs with an approximate threshold of 8 mg/kg/min, whereas CRP exhibited a linear positive dose-response relationship with MACCEs. Compared with individuals in the high eGDR and low CRP group (eGDR > 8 and CRP < 3), those in the low eGDR and high CRP group (eGDR ≤ 8 and CRP ≥ 3) showed the highest risk for MACCEs (hazard ratio [HR] = 2.282, 95% confidence interval [CI] 1.749-2.978). Mediation analysis indicated that CRP levels mediated 12.3% of the correlation between eGDR and MACCEs. Conclusion: eGDR showed a negative correlation with CRP levels, and their synergistic relationship enhanced the prediction of MACCEs in non-diabetic patients undergoing CABG. Additionally, CRP levels partially mediated the association between eGDR and MACCEs. Anti-inflammatory treatment for non-diabetic individuals with high IR who underwent CABG may offer further benefits.
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