ArticleOpen medicine (Warsaw, Poland)2025
Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study.
Article in Open medicine (Warsaw, Poland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Previous research has indicated a possible association between asthma and ankylosing spondylitis (AS). Methods: We pinpointed single nucleotide polymorphisms linked to various forms of asthma and AS, employing them as instrumental variables for a bidirectional two-sample Mendelian randomization (TSMR) analysis. Our TSMR analysis focused on European populations to minimize racial confounding. Multivariate adjustments for body mass index (BMI), smoking, and alcohol use were performed to control for confounders. Colocalization analysis was used to validate MR findings and explore genetic links between asthma and AS. Results: Individuals with asthma and eosinophilic asthma exhibited a relatively higher risk of AS (asthma: OR 1.31, 95% CI 1.07-1.62, Conclusion: This study revealed that a positive causal connection between asthma, specifically eosinophilic asthma, and AS.
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