ArticleFrontiers in pharmacology2025
Cost-effectiveness of therapeutic drug monitoring of perampanel for pediatrics with epilepsy: real-world data.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Clinical validation of a patient-friendly saliva microsampling approach to monitor perampanel levels in people with epilepsy.Epilepsia · 2026Article
- Pharmacokinetics of Perampanel in Danish Paediatric Patients With Epilepsy Based on Therapeutic Drug Monitoring.Basic & clinical pharmacology & toxicology · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims: Increased plasma concentration of perampanel (PER) is associated with reduction in seizure frequency. It is unclear how much better therapeutic drug monitoring (TDM) is than without TDM in pediatric using PER. This study aims to estimate the effectiveness and cost-effectiveness of TDM of PER in children with epilepsy. Methods: An observational study was conducted to compare clinical and economic outcomes between the TDM and non-TDM groups. We used a Markov model to evaluate the cost-effectiveness of TDM from a healthcare system perspective based on data from an observation cohort study that included four health states. High cost-effectiveness thresholds were defined as < $12,814. One-way, probabilistic sensitivity analyses and scenario analyses were conducted to explore uncertainty. Results: TDM of the PER improved the 1-year seizure-free rate from 16.7% to 48.1% and the >50% reduction in seizure frequency from 58.3% to 83.3% in children with epilepsy (P = 0.035). The TDM of the PER is highly cost-effective, with an ICER of $732.90 per QALY gained (79.11% probability of being highly cost-effective). TDM was dominant, with an increased QALY of 0.86 and a decreased cost of $1,586.07 in children with newly diagnosed epilepsy. The number of days of hospitalization in the no response state, which is related to the cost of hospitalization, is the largest influencing factor. Conclusion: TDM of PER could reduce the seizure frequency and is cost-effective for children with epilepsy. TDM of the PER in newly diagnosed epilepsy patients is strongly dominant because of its improvement in efficacy and reduction in cost.
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