Evidence map›Paper›PMID 40661061›Full record

ArticleFrontiers in toxicology2025

An advancement in developmental and reproductive toxicity (DART) risk assessment: evaluation of a bioactivity and exposure-based NAM toolbox.

Iris Mueller, Ashraf Abdelkhaliq, Paul Carmichael, Matthew Dent, Marleen Feliksik, Luke Flatt, Jade Houghton, José M Horcas Nieto, Amer Jamalpoor, Predrag Kukic and 8 more

Abstract read
In one paragraph

Article in Frontiers in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. NAM journal · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Iris MuellerUnilever, Sharnbrook, United Kingdom.
Ashraf AbdelkhaliqUnilever, Sharnbrook, United Kingdom.
Paul CarmichaelUnilever, Sharnbrook, United Kingdom.
Matthew DentUnilever, Sharnbrook, United Kingdom.
Marleen FeliksikToxys, Oegstgeest, Netherlands.
Luke FlattToxys, Oegstgeest, Netherlands.
Jade HoughtonUnilever, Sharnbrook, United Kingdom.
José M Horcas NietoToxys, Oegstgeest, Netherlands.
Amer JamalpoorToxys, Oegstgeest, Netherlands.
Predrag KukicUnilever, Sharnbrook, United Kingdom.
Sophie MalcomberUnilever, Sharnbrook, United Kingdom.
Beate NicolUnilever, Sharnbrook, United Kingdom.
Gopal PawarUnilever, Sharnbrook, United Kingdom.
Claire PeartUnilever, Sharnbrook, United Kingdom.
Katarzyna PrzybylakUnilever, Sharnbrook, United Kingdom.
Magdalena SawickaUnilever, Sharnbrook, United Kingdom.
Katy WilsonUnilever, Sharnbrook, United Kingdom.
Kathryn WoltonUnilever, Sharnbrook, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditional chemical safety assessment involves identifying the lowest level of a chemical that impacts endpoints measured in standardized animal studies to establish human exposure limits.

Indexed as

bioactivitydevelopmental and reproductive toxicityexposurein siliconew approach methodologiesrisk assessment

Identifiers

PMID40661061
PMCPMC12256496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.