ArticleMedical physics2025
Evaluation of the TG-43 formalism for intraoperative radiotherapy dosimetry in glioblastoma treatment.
Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Beyond TG‑43: A PRISMA-based systematic review on model-based dose-calculation algorithms in brachytherapy.Journal of applied clinical medical physics · 2026Pooled it
- Evaluation of the TG-43 formalism for intraoperative radiotherapy dosimetry in glioblastoma treatment.Medical physics · 2025Article
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7 authors.
Funding
Abstract
backgroundIntraoperative radiation therapy (IORT) using the INTRABEAM system has shown promise in glioblastoma treatment. However, accurate dosimetry remains challenging due to the low-energy photons used and the heterogeneity of tissues in the brain. Current clinical practice relies on the TARGIT method, but more robust approaches, including the TG-43 formalism and Monte Carlo (MC) simulations, warrant investigation for potential improvements in dose calculation accuracy. PURPOSE: To evaluate the TG-43 dosimetry formalism for IORT dose calculations in glioblastoma treatment using the INTRABEAM system, comparing it with the TARGIT method and MC simulations.
methodsWe analyzed the dose distributions in 20 patients from the INTRAGO trial. The TG-43 formalism was validated against MC simulations in water (
resultsTG-43 showed good agreement with
conclusionsThe TG-43 formalism provides a reasonable compromise between accuracy and computational efficiency for IORT dose calculations in glioblastoma treatment. It offers improved accuracy over TARGIT while being significantly faster and thus more feasible for intraoperative use than full MC simulations. Implementation of validated volumetric dose calculation methods like TG-43 has the potential to improve the accuracy of IORT treatment planning and OAR dose assessment.
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