ArticleMedical physics2025
Design, fabrication, commissioning, and dosimetric verification of a GRID collimator for proton SFRT on a compact proton therapy machine.
Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A review on radiochromic film dosimetry in radiation therapy.Journal of applied clinical medical physics · 2025Review
- Design, fabrication, commissioning, and dosimetric verification of a GRID collimator for proton SFRT on a compact proton therapy machine.Medical physics · 2025Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProton GRID radiotherapy (RT) is an extension of photon spatially fractionated radiation therapy (SFRT) techniques for bulky invasive tumors. It has been hypothesized that GRID RT improves the therapeutic ratio by minimizing normal tissue toxicities associated with treating bulky volumes while inducing abscopal radiobiologic effects. However, compact, synchrocyclotron-based proton therapy machines with large spot sizes pose unique technical challenges in implementing proton GRID RT. PURPOSE: The purpose of this work is to (a) design and model a collimating brass aperture within the RayStation treatment planning system (TPS), (b) validate the designed aperture by creating a commissioning plan and measuring the absolute and relative proton dose distributions delivered, and (c) perform a robustness analysis to determine the allowable mechanical tolerances and uncertainties during treatment delivery.
methodsA custom (27 × 21.5 × 5 cm
resultsExperimental measurements showed the best dosimetric agreements with the TPS calculations for optimization cylinder diameters of 10 mm with gamma passing rates of at least 97.9%. 1D absolute proton dose measurements with an ionization chamber showed agreement within 2.11% of TPS calculations once correcting for partial-volume averaging. Simulated mounting or setup errors within the TPS indicated a lateral positional requirement of ± 1.5 mm and a longitudinal snout positional requirement of ± 3 cm to achieve gamma passing rates of at least 90% (institutional standards).
conclusionWe have commissioned a brass collimator consisting of milled divergent apertures for clinical SFRT treatments via a proton GRID technique. This process included an assessment of dosimetric sensitivity of aperture positioning error, and also dosimetric evaluation of the aperture model as a brass support structure within the TPS. Future works entail the creation of clinical SFRT plans using different planning techniques and their respective dose comparisons.
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