ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2025
[He
Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo investigate the molecular mechanism by which He's Yangchao recipe improves ovarian function in premature ovarian insufficiency (POI) mice through intestinal flora modulation.
methodsForty female ICR mice (aged 6-8 weeks) were intraperitoneally injected with cyclophosphamide (150 mg/kg) to establish a POI model, while 10 untreated mice served as the blank control. The cyclophosphamide-injected mice were randomly divided into four groups with 10 mice in each group: low-dose He's Yangchao recipe (crude herb, 6 g/kg), high-dose He's Yangchao recipe (crude herb, 25 g/kg), estradiol (positive control), and model control (distilled water). Treatments were administered daily by gavage for 6 weeks. Vaginal exfoliated cells were stained with Wright-Giemsa solution to monitor estrous cycles. Serum estradiol and follicle-stimulating hormone (FSH) levels were measured by enzyme-linked immunosorbent assay. Ovarian FSH receptor (FSHR) expression was assessed by immunohistochemistry. Fecal samples from blank control, model control, and high-dose groups underwent metagenomic sequencing to evaluate intestinal microbiota diversity and composition. Glycolysis-related proteins pyruvate kinase M2 (PKM2) and glucose transporter 4 (GLUT4) were analyzed by Western blotting and immunofluorescence.
resultsHe's Yangchao recipe restored estrous cyclicity, increased serum estradiol (
conclusionsHe's Yangchao recipe ameliorates POI in mice by remodeling intestinal flora structure, enhancing glycolytic activity, improving ovarian sex hormone secretion, increasing granulosa cell FSHR expression, and restoring estrous cyclicity.
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