Evidence map›Paper›PMID 40660819›Full record

ArticleTechnology in cancer research & treatment

A Translational Research Leveraging Diagnostic Accuracy of Innovations in MRI as a Model for Early Breast Cancer Detection in Uganda.

Alfred Bulamu, Gregory S Karczmar, Funmi Olopade, Zhen Ren, Vicent Mboizi, Steven Eyobu Odongo, Omoleye Olasubomi, Kevin Wamala, Victoria Walusansa, Henry Settaba

Erratum issuedAbstract read
In one paragraph

Article in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Alfred BulamuUganda Cancer Institute, Kampala, Uganda.ORCID 0009-0003-6951-4763
Gregory S KarczmarUniversity of Chicago, Chicago, USA.
Funmi OlopadeUniversity of Chicago, Chicago, USA.
Zhen RenUniversity of Chicago, Chicago, USA.ORCID 0000-0002-2262-4880
Vicent MboiziCenters for Disease Control and Prevention Global Health Uganda, Kampala, Uganda.ORCID 0000-0003-3504-5551
Steven Eyobu OdongoMakerere University, Kampala, Uganda.ORCID 0000-0002-6729-5478
Omoleye OlasubomiUniversity of Chicago, Chicago, USA.ORCID 0000-0002-6922-9298
Kevin WamalaUniversity of Chicago, Chicago, USA.
Victoria WalusansaUganda Cancer Institute, Kampala, Uganda.
Henry SettabaUganda Cancer Institute, Kampala, Uganda.

Funding

The Funding Mechanism of the Pilot TrialR01CA276652 · NCI · UNIVERSITY OF CHICAGO · PI Hiroyuki Abe, Gregory S. Karczmar · 2023 to 2026
$5.0M
NCI NIH HHS R01 CA276652
6 · The paper itself

Abstract

IntroductionBreast cancer remains a leading cause of cancer-related morbidity and mortality in sub-Saharan Africa, with Uganda experiencing a reported 5% annual increase in cases. Alarmingly, 87% of women in Uganda present with advanced-stage disease that is less responsive to treatment, contributing to the region's disproportionately low survival rate. Early breast cancer detection will be the fundamental intervention to reverse the mortality resulting from breast cancer in Uganda. This study aims to enhance breast cancer screening and early detection in Ugandan women who are at risk through innovative use of quantitative MRI to differentiate between benign and malignant breast lesions for women at risk.MethodsThe study prospectively recruited women at risk of breast cancer who underwent breast ultrafast DCE-MRI from July 2023 to April 2024. A 3.0-T MRI system with a16 channel breast dedicated coil was used with scan durations of up to 10 min. The T1 weighted pre-contrast, T1 weighted post-contrast, T1 weighted dynamic subtracted and Maximum Intensity projection (MIP) sequences were acquired and the histology blinded pharmacokinetic analysis for the breast lesion was done. The initial area under the curve in 30 s after contrast injection (

Indexed as

Breast NeoplasmsEarly Detection of CancerMagnetic Resonance ImagingAdultAgedBreastContrast MediaFemaleHumansMiddle AgedProspective StudiesROC CurveTranslational Research, BiomedicalUgandaContrast Mediabreast cancercancer early detectioncancer screeningquantitative MRIultrafast DCE-MRI

Identifiers

PMID40660819
PMCPMC12264417

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.