ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Cognitive impairment and dementia in Latin American individuals with parkinsonism and Parkinson's disease: A 10/66 Dementia Research Group study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Cognitive impairment and dementia in Latin American individuals with parkinsonism and Parkinson's disease: A 10/66 Dementia Research Group study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
20 authors.
Funding
Abstract
introductionThis study aimed to determine the associations between parkinsonism and Parkinson's disease (PD) with cognitive impairment and dementia in a multi-country cohort in Latin America, using data from the 10/66 Dementia Research Group.
methodsThis population-based prospective cohort study was conducted in six Latin American countries, including 11,321 participants 65 years of age or older living in urban and rural areas.
resultsAt baseline, the prevalence of cognitive impairment in people with parkinsonism and PD was 33% and 26%, respectively. Parkinsonism (odds ratio [OR] 2.2 [95% confidence interval [CI] 1.9-2.6] and PD (OR 1.9 [95% CI 1.4-2.4]) were individually associated with baseline cognitive impairment and incident dementia. The pooled sub-hazard ratios for dementia in fixed-effect meta-analysis were 1.5 (95% CI 1.2-1.9) for parkinsonism and 1.5 (95% CI 1.0-2.2) for PD. DISCUSSION: Parkinsonism and PD were cross-sectionally associated with cognitive impairment and prospectively associated with incident dementia. These findings underscore the importance of routine screening for cognitive impairment in individuals with parkinsonism and PD, to facilitate early detection and intervention strategies that mitigate adverse outcomes. HIGHLIGHTS: The present study is one of the first longitudinal investigations into the association of parkinsonism and Parkinson's disease (PD) with cognitive impairment and dementia incidence in Latin America. Parkinsonism and PD showed strong cross-sectional associations with cognitive impairment, with consistent estimates across countries, independent of demographic factors. Parkinsonism and PD were linked to a significantly higher incidence of dementia over a 4-year follow-up period. Findings emphasize the need for routine cognitive screening in Parkinsonism and PD.
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