ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Associations between mid-life social relationships and the risk of incident dementia: The ARIC study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Associations of plasma HDL subclasses with incident dementia risk in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Hearing aid effectiveness and probable dementia risk across 33 countries: A pooled analysis of seven cohorts.Cell reports. Medicine · 2026Article
- Associations between mid-life social relationships and the risk of incident dementia: The ARIC study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
introductionThis study aimed to assess whether mid-life social relationships are associated with a lower risk of late-life dementia.
methodsParticipants in the Atherosclerosis Risk in Communities (ARIC) study were assessed for social support and isolation (Visit 2;1990-1992). A composite measure, "social relationships," was generated. Incident dementia cases were identified following Visit 2 through 2019, using ongoing surveillance. Associations between mid-life social relationships and incident dementia were evaluated with Cox proportional-hazard regression models. Formal interaction tests examined whether sex or race modified this association.
resultsAmong 13,070 participants without dementia, those with strong social relationships in mid-life had a lower risk for developing dementia, compared to participants with poor mid-life social relationships. Neither sex nor race significantly modified this association. DISCUSSION: Stronger mid-life social relationships may have a potentially protective effect on dementia risk. Future studies evaluating psychosocial health at multiple time points in ethnically diverse populations are needed. HIGHLIGHTS: Psychosocial health is a modifiable risk factor for dementia. Stronger mid-life social relationships are associated with a lower risk of dementia. Social relationships may have a potentially protective effect on late-life outcomes. This study leveraged data collected from nearly 20 years of follow-up in 13,070 participants. Longitudinal data used in this study were captured in a population that is 24% Black.
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