Evidence map›Paper›PMID 40660743›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Five years of the Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (IMPACT-AD).

Joshua D Grill, Margaret D Mastrolorenzo, Heather M Snyder, Maria C Carrillo, Ronald C Petersen, Paul Aisen, Reisa Sperling, Kedir Hussen, Rema Raman

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Five years of the Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (IMPACT-AD).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joshua D GrillInstitute for Memory Impairments and Neurological Disorders, Departments of Psychiatry and Human Behavior and Neurobiology and Behavior, University of California, Irvine, Irvine, California, USA.
Margaret D MastrolorenzoAlzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA.
Heather M SnyderDivision of Medical and Scientific Relations and Medical Affairs, Alzheimer's Association, Chicago, Illinois, USA.
Maria C CarrilloDivision of Medical and Scientific Relations and Medical Affairs, Alzheimer's Association, Chicago, Illinois, USA.
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Paul AisenAlzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA.
Reisa SperlingDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Kedir HussenAlzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA.
Rema RamanAlzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA.

Funding

The Alzheimer's Clinical Trial Consortium - Down Syndrome Network (ACTC- DSN)U24AG057437 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Paul S. Aisen, RONALD C PETERSEN · 2018 to 2026
$198.4M
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Elizabeth Head · 2020 to 2026
$27.9M
NIA/AA for Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (NIA/AA IMPACT-AD Course)R25AG076392 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Joshua Grill, Rema Raman · 2022 to 2026
$2.1M
Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (NIA/AA IMPACT-AD) CourseU13AG067696 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GRILL, JOSHUA, RAMAN, REMA · 2020 to 2024
$375k
Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (IMPACT-AD) Alumni Scholar ConferenceR13AG067696 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Joshua Grill, Rema Raman · 2025 to 2026
$150k
Alzheimer's Association SG-20-693744NIA NIH HHS P30 AG066519NIA NIH HHS R13 AG067696NIA NIH HHS R25 AG076392NIA NIH HHS R25AG076392NIA NIH HHS U13 AG067696NIA NIH HHS U24 AG057437
6 · The paper itself

Abstract

backgroundFirst held in 2020, the Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (IMPACT-AD) is a program to train the next generation of Alzheimer's disease (AD) and related dementias (AD/ADRD) clinical trialists.

methodsIMPACT-AD includes didactic, workshop, and small group components.

resultsIMPACT-AD has trained 18 alumni-scholars (accepted from 424 applicants), of whom 67% were female. Forty-eight (26%) were the first in their family to attend college. Scholars included individuals from all racial and ethnic groups. Each year, participants demonstrated increased learning about AD/ADRD clinical trials through a pre/post-test model of knowledge assessments. Among those completing annual follow-up surveys, >84% remain in AD/ADRD trials careers, and 80% have experienced career advances or milestones. In the latter group, > 90% indicated that participating in IMPACT-AD contributed to this career growth. DISCUSSION: IMPACT-AD is a novel educational program that is achieving its goals. HIGHLIGHTS: Over 5 years, the Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (IMPACT-AD) has trained 188 scholars. The course has been accessible to a broad range of trainees who were diverse in professional and demographic backgrounds. Objective assessments indicate that participants gain knowledge through participation. Eighty-four percent of trainees have remained in Alzheimer's disease and related dementias (ADRD) trials careers. Eighty percent of alumni have experienced career advances; nearly all indicated that participating in the course contributed to their success.

Indexed as

Alzheimer DiseaseClinical Trials as TopicAcademies and InstitutesDementiaFemaleHumansMaleclinical trialseducationtraining

Identifiers

PMID40660743
PMCPMC12260129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.