ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Educational attainment, electroencephalographic rhythms, cortical structure, and cognitive performance over 2 years in older adults with subjective memory complaints and brain amyloidosis.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Elevated branched-chain amino acids linked to hippocampal volumes and cognitive improvement in mild cognitive impairment.Brain imaging and behavior · 2026Article
- Educational attainment, electroencephalographic rhythms, cortical structure, and cognitive performance over 2 years in older adults with subjective memory complaints and brain amyloidosis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
25 authors.
Funding
Abstract
introductionWe investigated whether older adults with subjective memory complaints (SMC) and amyloid-β accumulation may show clinical progression over 2 years, as measured by resting-state electroencephalographic (rsEEG), structural magnetic resonance imaging (sMRI), and cognitive variables, depending on educational attainment.
methodsWe analyzed these markers in 84 SMC participants from INSIGHT-Pre-AD study, grouped by amyloid-β deposition (
resultsIn amyloid-negative individuals, higher educational attainment was linked to greater posterior rsEEG alpha activity, possibly reflecting neuroprotective effects. Conversely, amyloid-positive individuals with higher educational attainment showed reduced posterior rsEEG alpha rhythms and lower parietal cortical thickness, potentially indicating compensatory mechanisms counteracting early amyloidosis and neurodegeneration. No longitudinal changes were found in either group over 2 years. DISCUSSION: Education had a stable influence on rsEEG, sMRI, and cognitive markers over 2 years in SMC individuals. Longer follow-up periods should be used to monitor brain status with those markers. HIGHLIGHTS: Education, subjective memory complaint (SMC), and brain amyloid-β deposition. Stable influence of education on resting-state electroencephalographic (rsEEG), structural magnetic resonance imaging (sMRI), and cognitive markers over 2 years. Compensatory mechanism of education against early amyloidosis and neurodegeneration. Longer follow-up periods to monitor brain status in SMC older adults with those markers.
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