ArticleCPT: pharmacometrics & systems pharmacology2025
Continuous-Time Markov Population PK/PD Modeling of Longitudinal EASI Categorical Score in Atopic Dermatitis Treated With Rocatinlimab, an Anti-OX40 Monoclonal Antibody.
Article in CPT: pharmacometrics & systems pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase 1, Open-Label, Multiple-Dose Study of KHK4083 in Subjects With Atopic Dermatitis
A Phase 2, Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Study of an Anti-OX40 Monoclonal Antibody (KHK4083) in Subjects With Moderate to Severe Atopic Dermatitis (AD)
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Authors and funding
9 authors.
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Abstract
Rocatinlimab (AMG 451/KHK4083) is a potential T-cell rebalancing therapy that inhibits and reduces the number of pathogenic T cells by targeting the OX40 receptor; it is associated with a progressive and sustained response for patients with moderate-to-severe atopic dermatitis (AD). This population pharmacokinetic-pharmacodynamic (PPK-PD) analysis of rocatinlimab analyzed the longitudinal relationship between drug exposure and response using a four-state continuous-time Markov model. The model was developed using a two-compartment PPK model for exposure based on five clinical studies and the categorical scores of Eczema Area and Severity Index (EASI) response from two clinical studies in AD (NCT03096223/NCT03703102). EASI categorical score was classified by percentage reduction from baseline (EASI
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Registered trials
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