Evidence map›Paper›PMID 40660350›Full record

Trial reportCritical care (London, England)2025

Cardiac index, SvO

Petr Ostadal, Dagmar Vondrakova, Richard Rokyta, Jiri Karasek, Andreas Kruger, Marek Janotka, Jan Naar, Jana Smalcova, Marketa Hubatova, Milan Hromadka and 4 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
In one paragraph

Trial report in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02301819 (ExtraCorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02301819 nacompletednot on this map

ExtraCorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock

TypeinterventionalSponsorNa Homolce HospitalRan2014 to 2023Enrolled122ConditionsCardiogenic ShockArmsVeno-arterial extracorporeal membrane oxygenation (ECMO), Early conservative therapy according to standard practice
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. [Extracorporeal life support (ECLS)-update 2025].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Petr OstadalDepartment of Cardiology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic. ostadal.petr@gmail.com.ORCID http://orcid.org/0000-0001-9550-222X
Dagmar VondrakovaDepartment of Cardiology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
Richard RokytaDepartment of Cardiology, Faculty of Medicine Pilsen, University Hospital, Charles University, Pilsen, Czech Republic.
Jiri KarasekHospital Liberec, Liberec, Czech Republic.
Andreas KrugerDepartment of Cardiology, Na Homolce Hospital, Prague, Czech Republic.
Marek JanotkaDepartment of Cardiology, Na Homolce Hospital, Prague, Czech Republic.
Jan NaarDepartment of Cardiology, Na Homolce Hospital, Prague, Czech Republic.
Jana Smalcova2nd Department of Medicine, Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
Marketa Hubatova2nd Department of Medicine, Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
Milan HromadkaDepartment of Cardiology, Faculty of Medicine Pilsen, University Hospital, Charles University, Pilsen, Czech Republic.
Stefan VolovarDepartment of Cardiology, Faculty of Medicine Pilsen, University Hospital, Charles University, Pilsen, Czech Republic.
Miroslava SeyfrydovaDepartment of Cardiology, Faculty of Medicine Pilsen, University Hospital, Charles University, Pilsen, Czech Republic.
Ales Linhart2nd Department of Medicine, Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
Jan Belohlavek2nd Department of Medicine, Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.

Funding

Agentura Pro Zdravotnický Výzkum České Republiky 15-27994AUniverzita Karlova v Praze Cooperatio Cardiovascular Sciences
6 · The paper itself

Abstract

backgroundImmediate initiation of extracorporeal membrane oxygenation (ECMO) has not demonstrated benefit in individuals diagnosed with cardiogenic shock based on the presence of hypotension. The relationship between other hemodynamic or metabolic parameters and clinical outcomes, with or without ECMO, is not fully understood.

methodsThe Extracorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock (ECMO-CS) trial randomly assigned 117 patients diagnosed with cardiogenic shock to 2 groups: immediate initiation of ECMO or early conservative strategy. The present post-hoc analysis investigated the clinical efficacy of immediate ECMO therapy in subgroups with cardiogenic shock-more specific characteristics: low cardiac index, low venous oxygen saturation (SvO

resultsData regarding cardiac index were available for 58 patients. In the subgroup with cardiac index < 2.2 L/min/m

conclusionsMeasurement of cardiac index, pCO

trial registrationNCT02301819. Retrospectively registered 26 November 2014.

Indexed as

Carbon DioxideCardiac OutputExtracorporeal Membrane OxygenationOxygen SaturationShock, CardiogenicAgedFemaleHumansMaleMiddle AgedTreatment OutcomeCarbon DioxideCardiogenic shockClinical trialExtracorporeal membrane oxygenationTherapy

Identifiers

PMID40660350
PMCPMC12261638

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.