ArticleJournal of translational medicine2025
The rise of exosome-mediated mechanisms in MSC therapy.
Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Comparative Analysis of Different Origin-Derived Exosomes for Future Regenerative Endodontic Therapies: A Systematic Review.Clinical, cosmetic and investigational dentistry · 2026Review
- Current status and new horizons in stem cell therapy in cardiovascular regenerative medicine (CaVaReM): an update.European journal of medical research · 2025Review
- The anti-inflammatory effects of mesenchymal stem cells and their research progress in hematopoietic stem cell transplantation: A comprehensive review.Cell transplantationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGraft-versus-host disease (GVHD) remains a critical complication following allogeneic hematopoietic cell transplantation. Mesenchymal stromal cells (MSCs) have demonstrated promising immunomodulatory effects in mitigating GVHD. Despite the growing body of research, a comprehensive bibliometric evaluation of MSCs in GVHD is still lacking.
objectiveTo perform a bibliometric analysis of global research on MSC-based therapies for GVHD using Citespace and VOSViewer, with the aim of mapping publication trends, collaboration networks, and emerging research hotspots.
methodsPublications from 2010 to 2023 were retrieved from the Web of Science using targeted search strategies. Data analysis was conducted using Citespace, VOSViewer, and the R package "bibliometrix" to construct co-authorship, co-citation, and keyword networks. Visualization maps were generated to illustrate publication trends, geographic distributions, and thematic evolution in MSC-GVHD research.
resultsA total of 875 relevant publications from 58 countries were identified. The analysis revealed a substantial increase in research output over the past decade, with a noTable focus on extracellular vesicle and exosome-mediated mechanisms in MSC therapy. Prominent collaboration networks were observed among leading countries, notably between the United States and China, and key authors and institutions were delineated. Emerging hotspots and trends in MSC-GVHD research were identified, underscoring areas of potential translational significance.
conclusionThis bibliometric study provides a comprehensive overview of the evolving landscape of MSC research in GVHD. The findings highlight significant global trends and collaboration patterns that can inform both future basic research and clinical translation. These insights are critical for guiding further exploration and optimization of MSC-based therapeutic strategies in GVHD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.