Evidence map›Paper›PMID 40660260›Full record

ArticleJournal of nanobiotechnology2025

Human adipose-derived mesenchymal stem cell-derived exosomes induce epithelial remodeling and anti-scar healing revealed by single-cell RNA sequencing.

Yu Fu, Jun-Ling Xie, Xing-Liao Zhang, Guang-Ming Xie, Xin-Min Zhang, Yao-Ting Han, Meng-Meng Xu, Jing Zhang, Jun Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yu Fu *Research Center for Translational Medicine at East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Jun-Ling Xie *Research Center for Translational Medicine at East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Xing-Liao Zhang *Research Center for Translational Medicine at East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Guang-Ming XieResearch Center for Translational Medicine at East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Xin-Min ZhangResearch Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, 200092, China.
Yao-Ting HanResearch Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, 200092, China.
Meng-Meng XuResearch Center for Translational Medicine at East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Jing ZhangResearch Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, 200092, China. 96755@tongji.edu.cn.
Jun ZhangResearch Center for Translational Medicine at East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China. 92870@tongji.edu.cn.

Funding

China Postdoctoral Science Foundation 2022M722409National Natural Science Foundation of China 82401387The Peak Disciplines (Type IV) of Institutions of Higher Learning in Shanghai NA
6 · The paper itself

Abstract

The scar-free healing remains a clinical challenge, and requires the concerted efforts of multiple cell types, such as keratinocytes and fibroblasts. Exosomes derived from human adipose-derived mesenchymal stem cells (hADSC-Exos) have emerged as a promising therapeutic option. Nonetheless, a thorough understanding of the mechanisms underlying regenerative healing in response to hADSC-Exos treatment is still lacking. Here, we performed high-resolution single-cell RNA sequencing analysis of adult wild-type and hADSC-Exos-treated mice at postoperative day (POD) 14. hADSC-Exos influenced epithelial cells and fibroblasts, leading to scar-free wound healing. Among the epithelial cell subtypes, Lymphoid enhancer binding factor 1

Indexed as

Adipose TissueCicatrixExosomesMesenchymal Stem CellsWound HealingAnimalsEpithelial CellsEpithelial-Mesenchymal TransitionFibroblastsHumansKeratinocytesMaleMiceMice, Inbred C57BLSequence Analysis, RNASingle-Cell AnalysisTransforming Growth Factor beta1

Identifiers

PMID40660260
PMCPMC12261776

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.