ReviewMolecular cancer2025
Bridging the tumor microenvironment: the pivotal role of cancer-associated fibroblasts in tumor cachexia development.
Review in Molecular cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Cancer Cachexia Research and Drug Development: Lessons from Failures and the Promise of Immunomodulation.Cancers · 2026Review
- Reprogramming the Immunosuppressive Microenvironment in Triple-Negative Breast Cancer via FAP-Targeted Nanoprobes for Multimodal Imaging and Photothermal Therapy.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Heterogeneity and plasticity of cancer-associated fibroblasts.Nature cancer · 2026Review
- Autophagy in cancer-associated fibroblasts: its role in gastrointestinal cancers.Molecular cancer · 2026Review
- High-Dose Tramadol Enhances the Proliferative and Invasive Potential of Pancreatic Ductal Adenocarcinoma in Mice Through Microenvironmental Alteration.Pain research & management · 2026Article
- A novel prognostic and immune-related biomarkerTranslational cancer research · 2025Article
- Association Between Dietary Vitamin K Intake With Cancer Cachexia and Mortality: NHANES 1999-2018.Food science & nutrition · 2025Article
- Correction: Bridging the tumor microenvironment: the pivotal role of cancer-associated fibroblasts in tumor cachexia development.Molecular cancer · 2025Article
- The impact of cachexia index combined with BMI trajectory on survival outcomes in patients with cancer cachexia.Frontiers in nutrition · 2025Article
- Elucidating the Nexus of Mitochondrial Dysfunction and Oncometabolite Accumulation in Tumorigenesis.Nigerian medical journal : journal of the Nigeria Medical AssociationReview
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
Abstract
Tumor cachexia represents a complex and multifaceted metabolic syndrome that profoundly affects the quality of life and survival rates of individuals. It is highly prevalent in advanced cancer patients and is characterized by severe weight loss, muscle wasting, and systemic inflammation. The tumor microenvironment (TME) is pivotal in cancer formation and progression, where cancer-associated fibroblasts (CAFs) emerge as significant contributors. CAFs are a major component of the TME, and their interactions with tumor cells and other stromal elements contribute to various aspects of cancer biology, including tumor growth, metastasis, and resistance to therapy. Importantly, CAFs have been implicated in the pathogenesis of tumor cachexia through their ability to modulate inflammation, metabolic reprogramming, and immune responses. Given the intricate interplay between the TME, CAFs, and cachexia, understanding the mechanisms underlying these interactions is essential for developing effective therapeutic strategies to mitigate cachexia and improve patient outcomes. This review aims to provide a comprehensive overview of the roles of CAFs within the TME during cancer progression and the development of cachexia, highlighting the potential for targeting CAFs as a novel therapeutic approach.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.