ArticleBMC complementary medicine and therapies2025
Pharmacology and metabolomic reveal Polysaccharides from polygonatum sibiricum ameliorate the diabetic osteoporosis in zebrafish.
Article in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Medicine-food homologous bioactives in metabolic dysregulation-associated osteoporosis: a review of preclinical evidence and potential liver-bone and gut-bone actions.Chinese medicine · 2026Review
- Synthesis, Optimization, and Evaluation of a New Sustained-Release Food Formulation forFoods (Basel, Switzerland) · 2026Article
- Molecular mechanisms and preclinical evidence of natural products in diabetic osteoporosis: a review.Frontiers in endocrinology · 2026Review
- Therapeutic Efficacy of Soy-Derived Bioactives: A Systematic Review of Nutritional Potency, Bioactive Therapeutics, and Clinical Biomarker Modulation.Foods (Basel, Switzerland) · 2025Review
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10 authors.
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Abstract
backgroundPrevious studies found that Polygonatum sibiricum polysaccharide (PSP) exhibited anti-inflammatory and anti-oxidative effects on type 2 diabetes (T2DM). However, the roles and detailed mechanisms of PSP on the anti-diabetic osteoporosis are still poorly defined. The purpose of this study was to identify the detailed mechanisms of PSP-induced anti-diabetic osteoporosis.
methodsThe roles of PSP on diabetic osteoporosis were evaluated on a T2DM zebrafish model. Furthermore, the changes of related physiological indicators and metabolites in adult zebrafish (Danio rerio) were investigated by pharmacology and metabolomic analyses.
resultsResults showed that PSP significantly reduced the blood glucose content and induced caudal fin regeneration. Metabolomic analysis found that the key metabolites involved in arachidonic acid metabolism, PPAR signaling pathway, linoleic acid metabolism, steroid hormone biosynthesis, amino acid biosynthesis and metabolism, alpha-Linolenic acid metabolism, sphingolipid signaling pathway were affected by PSP treatment. Among these, PSP reversed the trend changes of several metabolites, such as L-aspartic acid, choline, and propionylcarnitine. Besides, further changes of TNF-α and IL-1β transcripts suggested that the proinflammatory cytokines were also involved in the PSP-triggered anti-diabetic osteoporosis.
conclusionAbove findings provided the theoretical basis for the use to plant PSP as food ingredients or bioactive compounds in natural health products on diabetic osteoporosis.
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