Evidence map›Paper›PMID 40660178›Full record

ArticleBMC biology2025

Organic cation transporter 3 on neuronal mitochondria mediates MPP

Ao Guan, Sida Han, Suzhen Liang, Weiwei Shen, Min Guo, Mei Cui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ao Guan *Department of Neurology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Sida Han *Department of Neurology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Suzhen LiangDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Weiwei ShenDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Min GuoDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, 200040, China. guo_min@fudan.edu.cn.
Mei CuiDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, 200040, China. cuimei@fudan.edu.cn.

Funding

Ministry of Science and Technology of China STI2030-Major Projects 2030 2021ZD0201806National Natural Science Foundation of China 82101336National Natural Science Foundation of China 82271221Shanghai Municipal Health Commission 20234Z0013
6 · The paper itself

Abstract

backgroundMitochondria play crucial roles in cellular metabolism, and metabolite compartmentalization significantly impacts mitochondrial function and disease pathophysiology. MPP

resultsOCT3 was detected in the mitochondria fraction of SH-SY5Y cells, located on both the inner membrane and outer membrane. Following MPP

conclusionsHere we found that OCT3 on neuronal mitochondria serves as an effective MPP

Indexed as

1-Methyl-4-phenylpyridiniumMembrane Transport ProteinsMitochondriaNeuronsOrganic Cation Transport ProteinsAnimalsCell Line, TumorHumansOrganic Cation Transporter 31-Methyl-4-phenylpyridiniumMembrane Transport ProteinsOrganic Cation Transporter 3Organic Cation Transport ProteinsMitochondriaMPP+NeurodegenerationOrganic cation transporter 3TIMM22

Identifiers

PMID40660178
PMCPMC12261742

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.