ArticleBMC biology2025
Adar contributes to genome integrity by regulating R-loop homeostasis in Drosophila.
Article in BMC biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Cross-Cohort Evidence of Editome Dysregulation and Cell Growth-Related IGFBP7 Recoding Driven by ADARB1 in Fuchs Endothelial Corneal Dystrophy.Investigative ophthalmology & visual science · 2026Article
- The Tale of the Guanosine Tract in Repeat Expansion Disorders.Molecular neurobiology · 2026Review
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Authors and funding
9 authors.
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Abstract
backgroundAdenosine deaminase acting on RNA (Adar) is a critical enzyme involved in post-transcriptional epigenetic regulation through adenosine-to-inosine (A-to-I) RNA editing. However, the biological role and regulatory mechanisms of Adar remain largely unknown.
resultsUsing Drosophila as a model, we found that loss of Adar leads to spontaneous genome instability characterized by DNA damage and mitotic defects. Genome-wide ssDRIP-seq revealed global R-loop accumulation in Adar mutants, particularly at gene promoters, introns, and repetitive regions including telomeric retrotransposons. Notably, overexpression of RNase H1 (RNH1) suppressed R-loop accumulation and rescued genome instability in Adar-deficient flies. Strikingly, a catalytically inactive Adar mutant (E374A), which lacks A-to-I editing activity, retained its ability to suppress R-loop accumulation and preserve genome integrity.
conclusionsOur findings identify a novel editing-independent role of Adar in maintaining genome stability via regulation of R-loop homeostasis. This work highlights the evolutionarily conserved functions of Adar beyond RNA editing and establishes Drosophila as a valuable model to study R-loop-mediated genomic instability.
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