ArticleBMC veterinary research2025
Comparative in vitro assessment of oak (Quercus infectoria) and Carob (Ceratonia siliqua) extracts as natural alternatives to metronidazole against Trichomonas gallinae.
Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTrichomonas gallinae, a protozoan parasite, is responsible for avian trichomoniasis, leading to significant morbidity and mortality, particularly among juvenile pigeons. Although metronidazole is the standard treatment, its potential for inducing resistance has prompted exploration of herbal extracts as alternative therapeutic options. This study aims to compare metronidazole's antitrichomonal effects with oak (Quercus infectoria) extracts and carob (Ceratonia siliqua) on T. gallinae in vitro.
methodsT. gallinae samples were collected from infected pigeons. For the in vitro study, multiwell plates were used with different concentrations (5, 10, 25, 50, and 100 µg/mL).
resultsThe minimum inhibitory concentration (MIC) after 24 hr for Q. infectoria was 25 µg/mL, while for C. siliqua it was 50 µg/mL. In comparison, the MIC of metronidazole was also found to be 50 µg/mL.
conclusionsFindings suggest that Q. infectoria and C. siliqua extracts exhibit potent antitrichomonal activity, comparable to metronidazole, in inhibiting T. gallinae trophozoite growth in vitro, making them viable natural alternatives.
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