ArticleBMC ophthalmology2025
Correlations between the clinical characteristics of diabetic trochlear nerve palsy and diplopia severity.
Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Real-world data analysis of cranial nerve III, IV, and VI palsies: demographics, association factors, and comparative all-cause mortality.BMC ophthalmology · 2026Article
- Trochlear Nerve Palsy: A Systematic Review of Etiologies and Diagnostic Insights.Diagnostics (Basel, Switzerland) · 2025Review
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6 authors.
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Abstract
importanceFew literatures reported the clinical characteristics of diabetic trochlear nerve palsy, including demographic characteristics, involvement between both eyes, time of symptom onset, duration of diabetes, etc. Whether there is relevance between these data and the severity of diplopia deserves to be analyzed.
objectiveTo clarify the clinical characteristics of diabetic trochlear nerve palsy patients and their correlation with the severity of diplopia. DESIGN, SETTING, AND
participantsMedical records of 609 isolated trochlear nerve palsy patients admitted to the Ocular Motility Disorder Treatment Centre of the First Affiliated Hospital of Harbin Medical University between December 2018 and October 2024 were reviewed and 92 eligible cases were enrolled in this study. MAIN OUTCOMES AND MEASURES: To evaluate the orientation and severity of diplopia, all patients were examined with neuroimaging, completed the computerized diplopia test and were assessed with the Ocular Motor Nerve Palsy Scale.
resultsAmong the 92 patients aged 44 to 86 years (62.10 ± 8.04 years), the majority of the patients were male (n = 67, 73%)with no bilateral trochlear nerve palsy reported in all patients. The duration of diabetes ranged from 0.5 to 30 years (11.37 ± 8.02 years), and the time of symptom onset for all patients ranged from 2 to 111 days (14.68 ± 15.64 days). The average level of hemoglobin A1c (HbA1c) was 8.02 ± 1.48(%) and the average maximum vertical deviation was 5.38°±2.18°. A significant correlation was found between the duration of diabetes and the severity of diplopia (P = 0.026) but other indicators were not. The duration of diabetes was an independent risk factor for the severity of diplopia (P = 0.035, OR = 1.004, 95% CI, 1.001-1.008). CONCLUSIONS AND RELEVANCE: This retrospective study suggests that the duration of diabetes plays an important role in diabetic trochlear nerve palsy and a longer duration of diabetes could lead to more severe diplopia in patients. Findings of this study may provide help for clinical treatment and prognosis.
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