ArticleBMC cardiovascular disorders2025
Hemoglobin, albumin, lymphocyte, and platelet (HALP) score predict prognosis in patients with atrial fibrillation and acute coronary syndrome or undergoing percutaneous coronary intervention.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Prognostic value of the NAPLES score in patients undergoing LVAD implantation: comparison with established nutritional indices.BMC cardiovascular disorders · 2026Article
- HALP score adds prognostic information beyond STS for 2-year mortality after transcatheter aortic valve implantation: a two-center retrospective cohort study.BMC cardiovascular disorders · 2026Article
- CBC-derived inflammatory indices predict adverse outcomes in geriatric emergency patients with acute infectious diarrhea: a MIMIC-IV analysis.Scientific reports · 2026Article
- Reconsidering the Prognostic Role of the HALP Score in Rheumatic Mitral Stenosis.Clinical cardiology · 2026Article
- The prognostic value of hemoglobin-to-albumin ratio in critically ill patients with atrial fibrillation: A retrospective cohort study.Medicine · 2026Article
- Prognostic Value of HALP Score for In-Hospital Mortality in Patients with Infective Endocarditis.Journal of clinical medicine · 2026Article
- The Impact of Body Mass Index and Nutritional Status on Cardiac Electrophysiological Balance Using ICEB and ICEBc: A Cross-Sectional Approach.Journal of cardiovascular development and disease · 2026Article
- Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) Score as a Novel Biomarker for Predicting Coronary Slow Flow in Patients with Angina and/or Ischemia and Nonobstructive Coronary Arteries.Journal of clinical medicine · 2026Article
- Association of the HALP score with baseline and incident physical-cognitive comorbidity and mortality: evidence from the WCHAT and UK Biobank cohorts.Frontiers in public health · 2026Article
- A Comparative Analysis of Neutrophil-to-Lymphocyte Ratio, Systemic Immune-Inflammation Index, and Hemoglobin-Albumin-Lymphocyte-Platelet Score in Migraine.Journal of inflammation research · 2026Article
- Association of the Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) Score with 3-Month Outcomes After Lumbar Medial Branch Radiofrequency Ablation: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2025Article
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5 authors.
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Abstract
backgroundThe combination of hemoglobin, albumin, lymphocytes, and platelets (HALP) is a comprehensive index of nutrition and systemic inflammation. This study aimed to assess the association between HALP score and major adverse cardiovascular events (MACEs) in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI).
methods2182 patients with AF and ACS or undergoing PCI were recruited and followed up for a median survival time of 1128 (807–1391) days. The endpoint was the incidence of MACEs including all-cause death, myocardial infarction, stroke, non-central nervous system embolism, and ischemia-driven revascularization. Kaplan-Meier curve was used to compare the MACEs risk in four groups divided by the HALP quartile. Cox analysis was performed to assess the relationships between HALP and MACE risk. Restricted cubic spline (RCS) was used to clarify the non-linear correlation of HALP with MACEs risk.
resultsThe Kaplan-Meier curves showed statistically significant differences in outcomes among the four groups (log-rank P < 0.01). The results of Cox analysis demonstrated that compared with participants with low HALP scores, participants with the highest HALP score had a lower MACE risk [adjusted HR: 0.61 (95% CI (0.45–0.81), P < 0.01]. The RCS curve revealed that the HALP was non-linearly and L-shaped correlated with MACEs (P for overall = 0.02, P for nonlinear = 0.02). Two-stage Cox analysis showed that in patients with HALP scores < 44.95, for every 1-unit decrease in HALP, the risk of MACEs increased by 1.8%. Adding the HALP score into the GRACE model or CHA2DS2-VASc model significantly increased the original predictive value on MACEs or all-cause death.
conclusionsHigh HALP was associated with a reduced risk of MACEs risk in patients with AF and ACS or undergoing PCI. HALP may be a potential marker for independently predicting MACEs in patients with AF and ACS or undergoing PCI.
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