ArticleBMC urology2025
The role of Pan-Immune inflammation value and systemic Immune-Inflammation index as potential biomarkers in predicting infectious complications following retrograde intrarenal surgery.
Article in BMC urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Postoperative systemic inflammatory response syndrome risk in asymptomatic versus symptomatic ureteral stone patients undergoing ureteroscopy: A retrospective comparative study.The Journal of international medical research · 2026Article
- Linear association between the systemic immune-inflammation index and all-cause mortality in patients with interstitial lung disease: a retrospective cohort study.Frontiers in medicine · 2026Article
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Abstract
backgroundTo predict postoperative infectious complications by utilizing hemogram parameters and derived inflammation indices and to analyze patient-related risk factors to propose a nomogram.
methodsThe data of patients who underwent retrograde intrarenal surgery were reviewed. The patients were categorized into two groups: those without infectious complications (Group A) and those with infectious complications (Group B). Infectious complications were defined as fever persisting above 38 °C for 48 h and the presence of two or more systemic inflammatory response syndrome (SIRS) criteria. Hemogram parameters and inflammation indices were examined to predict infectious complications. The study utilized neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), along with the pan-immune-inflammation value (PIV) and systemic immune-inflammation index (SII).
resultsThe data of 658 cases were evaluated. No infectious complications were observed in 610 cases (92.7%), while 33 cases (5.0%) developed fever, and 15 cases (2.3%) met the criteria for SIRS. The optimal cut-off values for distinguishing between groups were determined as follows: >2.66 for NLR, > 122.5 for PLR, < 2.81 for LMR, > 619.4 for SII, and > 500.2 for PIV. Patients with PIV > 500.2 exhibited a 13.737-fold increase (95% confidence interval [CI]: 7.260-25.994) in infectious complications compared to those with PIV ≤ 500.2, making PIV the strongest predictor. The most significant factors in differentiating between the groups were, in order of importance, Charlson comorbidity index, stone volume, preoperative serum creatinine level, and preoperative double-J stent placement. These factors were analyzed using multivariate logistic regression alongside PIV and SII, and two models were constructed. The predictive power of Model 1 was determined as Cox & Snell R² = 0.269 and Nagelkerke R² = 0.661, while Model 2 had a Cox & Snell R² value of 0.264 and a Nagelkerke R² value of 0.648.
conclusionPIV and SII, derived from hemogram parameters, serve as predictive inflammatory indices for postoperative infectious complications. They provide valuable preoperative insight into the patient's immune and systemic inflammatory responses. When combined with other risk factors, these indices allow for the prediction of postoperative infectious complications.
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