ArticlePlant cell reports2025
The function of TaWOX14 in wheat genetic transformation.
Article in Plant cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Newly found functions and regulatory networks of WOX family: what else does the WOX say?Planta · 2026Review
- Plant Regeneration: Influencing Factors, Regulatory Networks, and Epigenetic Mechanisms.International journal of molecular sciences · 2026Review
- WUSCHEL in forest trees: evolutionary organizer, vascular architect, and totipotency switch.Plant molecular biology · 2026Review
- Molecular regulators of regeneration and strategies for overcoming genotype-dependent recalcitrance in wheat (Triticum aestivum).Communications biology · 2026Review
- Rapid Genetic Stabilisation of Transgenic and Edited Wheat Through Transformation of Immature Haploid Embryos.Plant biotechnology journal · 2026Article
- Molecular Regulators of In Vitro Regeneration in Wheat: Roles of Morphogenic Factors in Transformation, Genome Editing, and Breeding.International journal of molecular sciences · 2026Review
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Authors and funding
4 authors.
Funding
Abstract
key messageOverexpression of TaWOX14 can significantly improve the genetic transformation and genome editing efficiencies of some wheat immature embryos, and TaPLD serves as a promising candidate gene for haploid induction in wheat. Genetic transformation and genome editing systems have the potential for accelerating the breeding process in crops. However, their effectiveness is often limited by the regeneration efficiency of explants. The WUSCHEL-related homeobox (WOX) family, a group of plant-specific transcription factors, plays a crucial role in somatic embryogenesis. In wheat, WOX genes are categorized into three clades: ancient, intermediate, and WUS. In this study, we systematically analyzed the function of the WUS clade genes in wheat transformation. Our results demonstrated that overexpression of TaWOX14 significantly improved genetic transformation efficiencies in several wheat genotypes, including Fielder, Kenong199, Zhengmai7698, and Yangmai13. Furthermore, by combining the CRISPR-Cas9 system with TaWOX14, we observed enhanced genome editing efficiency in the wheat variety Fielder. Additionally, we explored the potential of TaPLD as a candidate gene for haploid induction in wheat. Based on the amino acid sequence of Zea mays PHOSPHOLIPASE D3 (ZmPLD3), we edited its homologs in wheat and identified a TaPLD-edited plant with a ploidy level intermediate between haploid and hexaploid. Overall, these findings are expected to accelerate the wheat breeding process by improving genetic transformation efficiency and identifying a potential haploid induction gene. Future research will focus on further characterizing the mechanisms of TaWOX14 and TaPLD, and exploring their applications in breeding programs.
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