Evidence map›Paper›PMID 40660043›Full record

ReviewJournal of robotic surgery2025

Advances in nanorobotics for gastrointestinal surgery: a new frontier in precision medicine and minimally invasive therapeutics.

Zixuan Rui, Sepehr Mehdizadeh, Mozhgan Abasi, Younes Pilehvar

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of robotic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zixuan RuiSir Run Run Hospital Nanjing Medical University, Nanjing, China.
Sepehr MehdizadehCellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.
Mozhgan AbasiDepartment of Tissue Engineering and Applied Cell Sciences, Faculty of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Younes PilehvarCellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran. ypilehvar@umsu.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanorobotics is catalyzing a paradigm shift in GI surgery by synergizing nanoscale engineering, synthetic biology, and intelligent computation to create a novel frontier in precision medicine. This review critically discusses the most recent experimental breakthroughs in surgical nanorobots-from bioinspired actuation to programmable materials to autonomous tumor ablation to closed-looped therapeutic feedback-and charts their development from static constructions to intelligent agents with the ability to navigate the dynamic gastrointestinal (GI) environment. Systematically, we review how nanorobots integrate with artificial intelligence (AI)-fortified platforms, overcome GI-specific obstacles, and can facilitate site-specific intervention with spatiotemporal precision. Based on state-of-the-art preclinical models, organoid studies in humans, and in vivo deployment, we analyze biodegradability, pharmacokinetics, and regulatory readiness in pursuit of first-in-human trials. Aside from technical innovation, this review also addresses grand challenges in autonomy, off-target control, and ethical-legal frameworks, calling for an integrated, cross-specialty format to facilitate clinical translation. In visualizing neural-controlled nanorobots, self-healing machines, and living biosensor networks, we outline the pathway towards intelligent, minimally invasive surgery at the molecular level. This work posits surgical nanorobotics not as an incremental innovation but as a transformative axis for convergent surgical therapeutics in the next generation. It is an academic wake-up call for the strategic coming of age in this field from experimental brilliance to translational inevitability.

Indexed as

Digestive System Surgical ProceduresMinimally Invasive Surgical ProceduresNanotechnologyPrecision MedicineRobotic Surgical ProceduresAnimalsArtificial IntelligenceHumansGastrointestinal surgeryMinimally invasive surgical proceduresNanomedicineNanorobotics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.