Evidence map›Paper›PMID 40660009›Full record

ArticleCardiovascular engineering and technology2025

Role of Neo-Sinus on Thrombogenicity of Aortic Valve Prostheses: Experimental Proof-of-Concept Study.

Saskia Thoenissen, Ilona Mager, Claudio A Luisi, Markus Mous, Thomas Schmitz-Rode, Ulrich Steinseifer, Johanna C Clauser

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Article in Cardiovascular engineering and technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Saskia ThoenissenDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University Hospital, Forckenbeckstr. 55, 52074, Aachen, Germany.
Ilona MagerDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University Hospital, Forckenbeckstr. 55, 52074, Aachen, Germany.
Claudio A LuisiDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University Hospital, Forckenbeckstr. 55, 52074, Aachen, Germany.
Markus MousDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University Hospital, Forckenbeckstr. 55, 52074, Aachen, Germany.
Thomas Schmitz-RodeInstitute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Ulrich SteinseiferDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University Hospital, Forckenbeckstr. 55, 52074, Aachen, Germany.
Johanna C ClauserDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University Hospital, Forckenbeckstr. 55, 52074, Aachen, Germany. clauser@ame.rwth-aachen.de.ORCID 0000-0002-9050-2391

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTranscatheter aortic valve replacement (TAVR) is the standard treatment for patients with aortic diseases at high surgical risk. Transcatheter heart valve prostheses (THV) are inserted into the aortic valve, creating a new area between the native and artificial leaflets. This area, known as neo-sinus, increases the thrombogenicity of THVs. But there is a lack of testing methods that evaluate thrombogenicity in vitro.

methodsTo analyze the flow field within the native sinus and the neo-sinus, Particle Image Velocimetry (PIV) was performed with a thrombosis tester. Additionally, a comparative study was conducted with porcine blood on two polycarbonate urethane valves, with and without neo-sinus, respectively. Blood samples collected every hour were analyzed for platelet count, coagulation via ROTEM parameters, and plasma-free hemoglobin. Thrombus formation was detected optically.

resultsThe PIV measurements yield a physiological flow field in the aortic root that were consistent with those reported in literature. The analyzed blood parameters reveal no obvious difference between the valve with neo-sinus and the valve without. A higher amount of thrombus material for the valve with neo-sinus was found.

conclusionThe visualized flow field shows low velocities and stagnation zones due to the presence of native leaflets. Clot formation at the heart valve prostheses are in accordance with in-vivo findings. The benchmark of the two valves indicates an increased thrombogenic potential due to the neo-sinus. The thrombosis tester simulates the natural environment after TAVR. Thereby, newly developed THVs can be evaluated in vitro and consequently optimized regarding their thrombogenicity.

Indexed as

Aortic ValveHeart Valve ProsthesisThrombosisTranscatheter Aortic Valve ReplacementAnimalsBlood CoagulationBlood Flow VelocityHemodynamicsMaterials TestingProof of Concept StudyProsthesis DesignRheologySus scrofaBlood testIn-vitro testingNeo-sinusPIV measurementsThrombogenicityTranscatheter aortic valve replacement

Identifiers

PMID40660009
PMCPMC12528357

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.