ReviewEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025
Differential miRNA signatures in Hepatitis E Virus Infection: Insights into acute, chronic, and pregnancy-related outcomes.
Review in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
2 authors.
Funding
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Abstract
purposeHepatitis E virus (HEV) is a positive single-stranded RNA virus that causes acute and chronic hepatitis with severe complications in pregnant women and immunocompromised individuals. HEV infection manifest asymptomatically or progress to fulminant hepatitis, liver failure, and extrahepatic manifestations such as neurological disorders and renal damage. MicroRNAs are non-coding RNA molecules that play a key role in diseases and viral pathogenesis, influencing viral replication and immune evasion through their interaction with host factors. In this review, we discuss the role of microRNAs described to date in hepatitis E infection, highlighting their impact on acute, chronic, and pregnancy-related clinical outcomes.
resultsmiR-122, miR-214, miR-221, and miR-222 participate in the HEV replication and immune evasion, while specific miRNA profiles distinguish acute and chronic hepatitis E. HEV poses severe risks in pregnancy, with miR-431, miR-654, and miR-1468 related to self-limiting infection, and miR-450b to acute liver failure. Studying these miRNAs lead to biomarkers and therapies for hepatitis E.
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