ArticleNature aging2025
Extracellular vesicles from antler blastema progenitor cells reverse bone loss and mitigate aging-related phenotypes in mice and macaques.
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Article in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
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Who cites it
14 citing papers in PubMed.
- Stem Cell-Derived Extracellular Vesicles for the Treatment of Osteoporosis: A Systematic Review of Preclinical Evidence.Biomedicines · 2026Review
- Pre-Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Extracellular vesicles and epigenetic aging clocks in tissue aging: an exosome-focused conceptual framework with a focus on skin.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Review
- A bioorthogonal nanoconcentrisome system for epigenetic and immunometabolic reprogramming of tissue regeneration in aged female rats.Nature communications · 2026Article
- Super homotypic targeting by surface engineering of extracellular vesicles.Nature biomedical engineering · 2026Article
- Therapeutic effects of mesenchymal stem cell-derived extracellular vesicles from different tissue sources on diminished ovarian reserve and the related mechanisms.Journal of nanobiotechnology · 2026Article
- Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signalling, in Aged Hippocampus.Journal of extracellular vesicles · 2026Article
- Immunoengineering in the field of tendon and bone regeneration: immunomodulatory biomaterials, delivery platforms, and preclinical models for chronic diseases.Frontiers in bioengineering and biotechnology · 2026Review
- Regulatory mechanisms of deer antler extracellular vesicles in multilevel tissue repair: a state-of-the-art review.Frontiers in pharmacology · 2026Review
- Regenerative extracellular vesicles reshape systemic aging: lessons from antler stem cells.International journal of biological sciences · 2026Article
- Longitudinal Characterization of GiantResearch (Washington, D.C.) · 2026Article
- Deer antler stem cell-derived exosomes: a regenerative medicine powerhouse from nature's own repair kit.Frontiers in cell and developmental biology · 2026Review
- Multimorbidity and animal models.Animal models and experimental medicine · 2025Review
- Stem-cell-derived extracellular vesicles in neurodegeneration and neuroaging: therapeutic potential and challenges.Extracellular vesicles and circulating nucleic acids · 2025Review
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Authors and funding
37 authors.
Yiming Hao *Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.ORCID http://orcid.org/0000-0002-3027-2686
Beibei Yu *Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.ORCID http://orcid.org/0000-0002-9076-5597
Mingze Qin *Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.ORCID http://orcid.org/0009-0006-4286-9662
Tao Qin *New Cornerstone Science Laboratory, Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Ecology and Environment, Northwestern Polytechnical University, Xi'an, China.ORCID http://orcid.org/0000-0002-0906-6335
Jianhong Wang *National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, China.ORCID http://orcid.org/0000-0002-0458-5507
Yitao WeiDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Chengxiang ZhaoDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Yaowen XingUnited Imaging Healthcare, Shanghai, China.
Yuan YuanNew Cornerstone Science Laboratory, Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Ecology and Environment, Northwestern Polytechnical University, Xi'an, China.
Tingfeng XueNew Cornerstone Science Laboratory, Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Ecology and Environment, Northwestern Polytechnical University, Xi'an, China.
Borui XueDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Yali ZhangNational Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, China.
Hongdi HuangNational Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, China.
Xiaomei YuNational Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, China.
Yunchao JiNational Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, China.
Minghao QiuNational Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, China.
Yufang ZhouNational Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, China.
Bing XiaDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Teng MaDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Shengyou LiDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Haining WuDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Xue GaoDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Yujie YangDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Lingli GuoDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Yongfeng ZhangDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Zhenguo WangDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Huiling SunNew Cornerstone Science Laboratory, Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Ecology and Environment, Northwestern Polytechnical University, Xi'an, China.
Xueli GaoNew Cornerstone Science Laboratory, Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Ecology and Environment, Northwestern Polytechnical University, Xi'an, China.
Zujian HuangSchool of Life Sciences, Xidian University, Xi'an, China.
Longbao LvNational Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, China.
Dongdong WuNational Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, China.ORCID http://orcid.org/0000-0001-7101-7297
Zhipeng LiInstitute of Antler Science and Product Technology, Changchun Sci-Tech University, Changchun, China.
Yonggang YaoNational Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, China. yaoyg@mail.kiz.ac.cn.ORCID http://orcid.org/0000-0002-2955-0693
Wen WangNew Cornerstone Science Laboratory, Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Ecology and Environment, Northwestern Polytechnical University, Xi'an, China. wenwang@nwpu.edu.cn.ORCID http://orcid.org/0000-0002-7801-2066
Zhuojing LuoDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China. zjluo@fmmu.edu.cn.ORCID http://orcid.org/0000-0003-3285-4636
Qiang QiuNew Cornerstone Science Laboratory, Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Ecology and Environment, Northwestern Polytechnical University, Xi'an, China. qiuqiang@nwpu.edu.cn.ORCID http://orcid.org/0000-0002-9874-271X
Jinghui HuangDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China. huangjh@fmmu.edu.cn.ORCID http://orcid.org/0000-0002-0991-0591
Funding
Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) STI2030-Major Project grant 2021ZD0200900Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) STI2030-Major Projects grants 2021ZD0203900Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) STI2030-Major Projects grants 2022ZD0205100National Natural Science Foundation of China (National Science Foundation of China) 32225009National Natural Science Foundation of China (National Science Foundation of China) 82122043National Natural Science Foundation of China (National Science Foundation of China) 82372404
Abstract
Antler blastema progenitor cells (ABPCs) are a distinct population of skeletal mesenchymal stem cells found in regenerating deer antlers, with strong stemness and renewal capacity in vitro. Stem cell-derived extracellular vesicles (EVs) are emerging as potential therapeutic candidates that can mediate donor cells' beneficial effects. Here, we tested the effects of ABPC-derived EVs (EVs
Indexed as
AgingAntlersExtracellular VesiclesMesenchymal Stem CellsAnimalsBone DensityDeerEpigenesis, GeneticFemaleMacaca mulattaMaleMiceMice, Inbred C57BLPhenotype
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.