Evidence map›Paper›PMID 40659961›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2025

What factors predict cervical sagittal alignment restoration after correction of thoracic adolescent idiopathic scoliosis with severe thoracic hypokyphosis? A multicenter retrospective study of 57 patients.

Giovanni Viroli, Alberto Ruffilli, Matteo Traversari, Mohammadreza Chehrassan, Javad Moeini, Marco Manzetti, Marco Ialuna, Cesare Faldini

Erratum issuedAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Comparison of cervical sagittal alignment in normal subjects and adolescents and young adults with idiopathic scoliosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Giovanni ViroliDepartment of Biomedical and Neuromotor Science-DIBINEM, University of Bologna, 1st Orthopaedic and Traumatologic Clinic, IRCCS Istituto Ortopedico Rizzoli, Via Giulio Cesare Pupilli 1, Bologna, 40136, Italy. virolig@gmail.com.ORCID http://orcid.org/0000-0003-4348-0983
Alberto RuffilliDepartment of Biomedical and Neuromotor Science-DIBINEM, University of Bologna, 1st Orthopaedic and Traumatologic Clinic, IRCCS Istituto Ortopedico Rizzoli, Via Giulio Cesare Pupilli 1, Bologna, 40136, Italy.
Matteo TraversariDepartment of Biomedical and Neuromotor Science-DIBINEM, University of Bologna, 1st Orthopaedic and Traumatologic Clinic, IRCCS Istituto Ortopedico Rizzoli, Via Giulio Cesare Pupilli 1, Bologna, 40136, Italy.
Mohammadreza ChehrassanBone and Joint reconstruction research center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.
Javad MoeiniBone and Joint reconstruction research center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.
Marco ManzettiDepartment of Biomedical and Neuromotor Science-DIBINEM, University of Bologna, 1st Orthopaedic and Traumatologic Clinic, IRCCS Istituto Ortopedico Rizzoli, Via Giulio Cesare Pupilli 1, Bologna, 40136, Italy.
Marco IalunaDepartment of Biomedical and Neuromotor Science-DIBINEM, University of Bologna, 1st Orthopaedic and Traumatologic Clinic, IRCCS Istituto Ortopedico Rizzoli, Via Giulio Cesare Pupilli 1, Bologna, 40136, Italy.
Cesare FaldiniDepartment of Biomedical and Neuromotor Science-DIBINEM, University of Bologna, 1st Orthopaedic and Traumatologic Clinic, IRCCS Istituto Ortopedico Rizzoli, Via Giulio Cesare Pupilli 1, Bologna, 40136, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeto evaluate changes in cervical sagittal alignment after correction of AIS with severe thoracic hypokyphosis (< 10°); to assess radiographical parameters predicting postoperative cervical sagittal alignment through multivariate regression analysis.

methodsA multicenter retrospective study included AIS patients with severe thoracic hypokyphosis. Treatment involved posterior spinal fusion with pedicle screws, Ponte osteotomies, differential rod contouring and DVR. Radiographic analysis was conducted preoperatively and at a minimum 2-year follow-up.

resultsAmong 57 patients, a significant improvement in T5-T12 thoracic kyphosis was noted at the last follow-up. Cervical Lordosis (CL) also significantly increased, with a remaining mismatch between ideal and actual postoperative CL. Correlation analyses revealed associations between thoracic kyphosis and postoperative CL. In patients with preoperative neutral or kyphotic CL, additional factors, such as TK apex-SVA, C5-T2° Change, and TK apex-scoliosis apex distance, correlated with CL changes.

conclusionPosterior correction of hypokyphotic AIS demonstrated significant CL improvement, yet a mismatch between ideal and achieved alignment persisted. The degree of thoracic and cervicothoracic alignment restoration correlated with spontaneous CL improvement. Overall, the study highlights the complexities of sagittal alignment in AIS.

Indexed as

Cervical VertebraeKyphosisLordosisScoliosisSpinal FusionThoracic VertebraeAdolescentChildFemaleHumansMaleRetrospective StudiesTreatment OutcomeAdolescent idiopathic scoliosisAISCervical kyphosisCervical sagittal alignmentSagittal balance

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.