ArticleSurgical endoscopy2025
The value of MRI and flexible sigmoidoscopy in detecting tumor regrowth in watch and wait rectal cancer patients undergoing active surveillance after total neoadjuvant therapy.
Article in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Pre-operative endoscopic assessment and MRI as predictors of pathological complete response and long-term survival in locally advanced rectal cancer after neoadjuvant therapy.Surgical endoscopy · 2026Article
- Report from the 27th Annual Western Canadian Gastrointestinal Cancer Consensus Conference on Colorectal Cancer, Calgary, Alberta, 26-27 September 2025: Advances in Colon and Rectal Cancer.Current oncology (Toronto, Ont.) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
aimPatients with locally advanced rectal cancer may avoid surgery if they develop a clinical complete response (cCR) to total neoadjuvant therapy (TNT). During surveillance, detection of local regrowth can be challenging. The ability of MRI to predict local regrowth is uncertain, especially when it differs from endoscopic findings. This study evaluates the ability of MRI and endoscopy to predict local regrowth in patients under surveillance for cCR after TNT.
methodAll rectal cancer patients in our institution from 2006 to 2020 who achieved cCR following TNT, and entered watch and wait (WW), with findings suspicious for local regrowth during surveillance and subsequently underwent surgery were assessed. The main outcomes were the ability of MRI to correctly identify the local regrowths and its correlation with endoscopy and pathology.
results1426 patients were diagnosed with locally advanced rectal cancer. 388 patients achieved cCR after TNT and underwent surveillance. 112 patients developed clinical and/or radiological findings suspicious of local regrowth. Of 99 patients who proceeded to surgery, 12 (12%) had a pathological complete response (pCR). For patients with an abnormal MRI only and normal endoscopy, pCR rate was 4/9 (44%). For patients with an abnormal endoscopy, pCR rates in those with a normal MRI and those with an abnormal MRI were 6/34 (18%) and 2/56 (4%), respectively (χ
conclusionIn rectal cancer patients achieving cCR after TNT, local regrowth without detectable endoscopic findings is rare. When isolated abnormal MRI findings occur, repeat radiologic surveillance prior to deciding on surgery may minimize unnecessary surgical interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.