Evidence map›Paper›PMID 40659924›Full record

ArticleJournal of human hypertension2025

Effectiveness of single-pill combination olmesartan/amlodipine/hydrochlorothiazide therapy in patients with apparent resistant hypertension.

Jaewon Oh, Wonho Kim, Gee-Hee Kim, Hack-Lyoung Kim, Sang-Don Park, Kyung Wan Min, Dongkeun Hyun, Jun Hwa Hong, Soo Lim, Ji-Hwan Bae and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of human hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jaewon OhDivision of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Wonho KimDivision of Cardiology, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Republic of Korea.
Gee-Hee KimDivision of Cardiology, Department of Internal Medicine, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
Hack-Lyoung KimDivision of Cardiology, Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-6703-1472
Sang-Don ParkDivision of Cardiology, Department of Internal Medicine, Inha University Hospital, Incheon, Republic of Korea.
Kyung Wan MinDivision of Endocrinology and Metabolism, Department of Internal Medicine, Eulji University School of Medicine, Seoul, Republic of Korea.
Dongkeun HyunDepartment of Neurosurgery, School of Medicine, Inha University, Incheon, Republic of Korea.
Jun Hwa HongDivision of Endocrinology, Department of Internal Medicine, Daejeon Eulji Medical Center, Eulji University School of Medicine, Daejeon, Republic of Korea.
Soo LimDepartment of Internal Medicine, Seoul National University College of Medicine, and Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Ji-Hwan BaeMedical Affairs Department, Daiichi Sankyo Korea Co., Ltd., Seoul, Republic of Korea.
Jinho ShinDivision of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea. jhs2003@hanyang.ac.kr.ORCID http://orcid.org/0000-0001-6706-6504
RESOLVE-INT Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This pioneering study investigated the real-life effectiveness of single-pill combination (SPC) antihypertensive therapy in patients with uncontrolled blood pressure (BP) and cardiovascular risk factors. After treatment with olmesartan medoxomil/amlodipine besylate/hydrochlorothiazide for 24 weeks, adults with apparent resistant hypertension had significantly reduced systolic BP and approximately 80% achieved target BP. SPC therapy may improve adherence in patients with pseudo-resistant hypertension and is a potentially effective treatment for resistant hypertension.

Indexed as

AmlodipineAntihypertensive AgentsBlood PressureHydrochlorothiazideHypertensionImidazolesTetrazolesAdultAgedDrug CombinationsDrug ResistanceDrug Therapy, CombinationFemaleHumansMaleMiddle AgedAmlodipineAntihypertensive AgentsDrug CombinationsHydrochlorothiazideImidazolesolmesartanOlmesartan MedoxomilTetrazoles

Identifiers

PMID40659924
PMCPMC12417203

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.