Article in Journal of computer-aided molecular design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
25 authors.
Lokesh RaviDepartment of Biomedical Sciences, School of Health Sciences, The Apollo University, Chittoor, Andhra Pradesh, 517127, India. dr.lokesh.ravi@gmail.com.ORCID 0000-0001-7365-7917
Pratishtha JainDepartment of Biotechnology, Faculty of Life and Allied Health Sciences, MS Ramaiah University of Applied Sciences, Bengaluru, Karnataka, 560054, India.ORCID 0009-0002-1010-4199
Ajith Kumar KDepartment of Life Sciences, Kristu Jayanti College (Autonomous), Bengaluru, Karnataka, 560077, India.ORCID 0000-0003-1882-4860
Jeevan Kumar MDepartment of Biomedical Sciences, School of Health Sciences, The Apollo University, Chittoor, Andhra Pradesh, 517127, India.ORCID 0000-0002-2708-5513
Mukti PandaDepartment of Biotechnology, School of Life Sciences, St Joseph's University, Bengaluru, Karnataka, 560027, India.ORCID 0009-0004-6652-7240
Harshitha SDepartment of Biotechnology, School of Life Sciences, St Joseph's University, Bengaluru, Karnataka, 560027, India.ORCID 0009-0008-4682-4861
Mohammed Abdul KareemDepartment of Chemistry, School of Chemical Sciences, St Joseph's University, Bengaluru, Karnataka, 560027, India.ORCID 0009-0002-0803-1197
K Sivani Yelchuri SaiDepartment of Zoology, School of Life Sciences, St Joseph's University, Bengaluru, Karnataka, 560027, India.ORCID 0009-0006-0803-1372
Ayman FathimaDepartment of Chemistry, School of Chemical Sciences, St Joseph's University, Bengaluru, Karnataka, 560027, India.ORCID 0009-0007-8514-4458
V JenshaDepartment of Biochemistry, School of Chemical Sciences, St Joseph's University, Bengaluru, Karnataka, 560027, India.ORCID 0009-0001-8517-3685
Adarsh Anurag RaiDepartment of Biotechnology, School of Life Sciences, St Joseph's University, Bengaluru, Karnataka, 560027, India.ORCID 0009-0008-9671-8426
Hida Amal FaizalDepartment of Biotechnology, School of Life Sciences, St Joseph's University, Bengaluru, Karnataka, 560027, India.ORCID 0009-0008-5667-9899
Shrivats S RDepartment of Chemistry, School of Chemical Sciences, St Joseph's University, Bengaluru, Karnataka, 560027, India.ORCID 0009-0004-0645-3892
Ankitha AjithDepartment of Biochemistry, School of Chemical Sciences, St Joseph's University, Bengaluru, Karnataka, 560027, India.ORCID 0009-0004-4790-7045
Derick YesudasDepartment of Chemistry, School of Chemical Sciences, St Joseph's University, Bengaluru, Karnataka, 560027, India.ORCID 0009-0007-6920-8378
Vaarruni SDepartment of Biochemistry, School of Chemical Sciences, St Joseph's University, Bengaluru, Karnataka, 560027, India.ORCID 0009-0003-0770-000X
Varshini SDepartment of Biotechnology, School of Life Sciences, St Joseph's University, Bengaluru, Karnataka, 560027, India.ORCID 0009-0000-3973-0244
Raksha ShettyDepartment of Zoology, School of Life Sciences, St Joseph's University, Bengaluru, Karnataka, 560027, India.ORCID 0009-0005-7288-9624
Aditi JhaDepartment of Biomedical Sciences, School of Health Sciences, The Apollo University, Chittoor, Andhra Pradesh, 517127, India.ORCID 0009-0009-1913-8732
Gundlapalli Saradha JanakiDepartment of Biomedical Sciences, School of Health Sciences, The Apollo University, Chittoor, Andhra Pradesh, 517127, India.ORCID 0009-0000-1093-2192
Varsha Hannah GeorgeDepartment of Biomedical Sciences, School of Health Sciences, The Apollo University, Chittoor, Andhra Pradesh, 517127, India.ORCID 0009-0004-8153-7551
Stalin NithaniyalBotanical Survey of India, Western Regional Centre, Pune, Maharashtra, 411001, India.ORCID 0000-0002-9799-1386
Mookkandi Palsamy KesavanDepartment of Chemistry, Hajee Karutha Rowther Howdia College, Uthamapalayam, Tamil Nadu, 625533, India.ORCID 0000-0002-9158-8043
Sajith Ahamed ADepartment of Microbiology, Hajee Karutha Rowther Howdia College, Theni District, Uthamapalayam, Tamil Nadu, India.ORCID 0000-0003-0707-1429
Sankara Narayanan ADepartment of Life Sciences, School of Sciences, GSFC University, Vadodara, Gujarat, 391750, India.ORCID 0000-0002-0603-6608
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Understanding the mechanism of action of anticancer agent plays a key role in effective clinical application of natural products. This study aims to identify an anti-cancer phytochemical with multi-target inhibition potential against non-small cell lung cancer. This study employs virtual screening of 8352 phytochemicals by molecular docking (AutoDock Vina & SeeSAR) to identify potential inhibitor of KRas, SMYD3, ALDH1 and GFPT2 proteins. Molecular Dynamics Simulation (Desmond) simulation for extensive 500 ns duration was performed to validate the inhibition potential. Followed by cell biology studies i.e., MTT assay, Flowcytometry and qRT-PCR analysis to confirm the mechanism of action. Molecular Docking and Molecular Dynamics Simulation studies predicted Heptadecanol as potential inhibitor of three drug targets, i.e., KRas, SMYD3 and GFPT2. In-vitro cytotoxicity assay confirmed the anti-cancer cytotoxicity of Heptadecanol with a significant IC
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
"Heptadecanol" a phytochemical multi-target inhibitor of SMYD3 & GFPT2 proteins in non-small cell lung cancer: an in-silico & in-vitro investigation. · full record | OpenQuestion