Evidence map›Paper›PMID 40659881›Full record

ArticleCommunications biology2025

Deciphering the role of CAPZA2 in neurodevelopmental disorders: insights from mouse models.

Mei Guo, Liming Liu, Xiao Mao, Manyu Xiao, Xiaobin He, Xing Pan, Yuewen Chen, Wanying Yi, Qibin Li, Xianglan Piao and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mei GuoCenter on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, Beijing, China.
Liming LiuCenter on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, Beijing, China.
Xiao MaoNational Health Commission Key Laboratory for Birth Defect Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, China.
Manyu XiaoCenter on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, Beijing, China.
Xiaobin HeGenevoyager (Wuhan) Co. Ltd, Wuhan, China.
Xing PanGenevoyager (Wuhan) Co. Ltd, Wuhan, China.
Yuewen ChenChinese Academy of Sciences Key Laboratory of Brain Connectome and Manipulation, Shenzhen Key Laboratory of Translational Research for Brain Diseases, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, Guangdong, China.
Wanying YiGuangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen, Guangdong, China.
Qibin LiRefunction Biosciences, Shenzhen, China.
Xianglan PiaoKey Laboratory of Ethnomedicine for Ministry of Education, School of Pharmacy, Minzu University of China, Beijing, China.
Hua WangThe Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan children's hospital), Clinical Medical Research Center for Hereditary Birth Defects and Rare Diseases, Hunan, China. wanghua213@aliyun.com.ORCID http://orcid.org/0000-0001-6178-7108
Yang DuCenter on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, Beijing, China.ORCID http://orcid.org/0000-0002-9013-3178
Yong ChengCenter on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, Beijing, China. yongcheng@muc.edu.cn.ORCID http://orcid.org/0000-0002-7529-4408

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intellectual disability affects 1-3% of the global population, with many unidentified genetic causes. This study investigates the role of CAPZA2, an actin cytoskeleton regulator, in neurodevelopmental disorders using CAPZA2 heterozygous knockout (CAPZA2

Indexed as

CapZ Actin Capping ProteinNeurodevelopmental DisordersAnimalsBehavior, AnimalBrainDisease Models, AnimalFemaleMaleMaze LearningMiceMice, KnockoutNeuronal PlasticitySocial BehaviorCapza2 protein, mouseCapZ Actin Capping Protein

Identifiers

PMID40659881
PMCPMC12259879

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.