Evidence map›Paper›PMID 40659877›Full record

SynthesisPediatric cardiology2026

Outcomes of Primary Vs. Staged Repair in 4628 Neonates with Symptomatic Tetralogy of Fallot: A Systematic Review and Meta-analysis.

Mohamed Nabih Bashir, Mohamed Hamouda Elkasaby, Mohamed Mohamed Belal, Loubna Mohamed Saad, Basma Badrawy Khalefa, Mazen Negmeldin Aly Yassin, Malak Mohamed Abd El-Hameed, Safaa Mohammad Almawas, Rawan Medhat El-Gayar

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Pediatric cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohamed Nabih BashirFaculty of Medicine, Alexandria University, Alexandria, Egypt. mohamed.ahmed1807@alexmed.edu.eg.ORCID http://orcid.org/0000-0001-7363-5515
Mohamed Hamouda ElkasabyFaculty of Medicine, Al-Azhar University, Cairo, Egypt.ORCID http://orcid.org/0000-0003-1092-7144
Mohamed Mohamed BelalFaculty of Medicine, Alexandria University, Alexandria, Egypt.ORCID http://orcid.org/0000-0002-8688-0349
Loubna Mohamed SaadFaculty of Medicine, Alexandria University, Alexandria, Egypt.ORCID http://orcid.org/0000-0002-7181-4402
Basma Badrawy KhalefaFaculty of Medicine, Ain Shams University, Cairo, Egypt.ORCID http://orcid.org/0000-0002-8897-1682
Mazen Negmeldin Aly YassinFaculty of Medicine, Helwan University, Cairo, Egypt.ORCID http://orcid.org/0000-0002-9605-6548
Malak Mohamed Abd El-HameedFaculty of Medicine, Zagazig University, Zagazig, Egypt.ORCID http://orcid.org/0000-0003-0542-0365
Safaa Mohammad AlmawasFaculty of Medicine, Mansoura University, Mansoura, Egypt.ORCID http://orcid.org/0000-0001-5785-3950
Rawan Medhat El-GayarFaculty of Medicine, Zagazig University, Zagazig, Egypt.ORCID http://orcid.org/0000-0001-8613-2052

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are two strategies to treat neonates with symptomatic tetralogy of Fallot (TOF), primary repair (PR) and staged repair (SR). There is still a debate on the best surgical strategy. We aim to compare PR and SR regarding mortality and comorbidities. We executed a systematic search on PubMed, Embase, Scopus, Web of Science (WOS), and Cochrane Central till January 10, 2025. We included studies with neonates with symptomatic TOF who received an intervention within the first 30 days of life, either with SR or PR. The primary outcomes were in-hospital, 30-day, and 2-year mortality rates. We used Review Manager to calculate the risk ratio (RR) and its 95% confidence interval (CI) for categorical variables and the mean difference (MD) and its 95% CI for continuous outcomes. A P-value less than 0.05 was considered significant. The I-squared test was used to assess heterogeneity. The RRs of mortality at 30 days and 2 years were comparable between both approaches (RR = 0.53; [95% CI = 0.22-1.27], P = 0.15) and (RR = 1.22; [95% CI = 0.0.99-1.51], P = 0.07) respectively. While the length of hospital stay (MD = 18.47 days; [95% CI = 10.87-26.08], P < 0.00001), length of intensive care unit stay (MD = 4.18 days; [95% CI = 3.12-5.23], P < 0.00001), and cardiopulmonary bypass time (MD = 46,47 day; [95% CI = 37.71-55.24], P < 0.00001), all were longer with SR. PR and SR strategies are equivalent regarding short- and long-term mortality in neonates with symptomatic TOF.

Indexed as

Cardiac Surgical ProceduresTetralogy of FallotHospital MortalityHumansInfant, NewbornLength of StayTreatment OutcomePrimary repairStaged repairTetralogy of Fallot

Identifiers

PMID40659877

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.