Evidence map›Paper›PMID 40659861›Full record

ArticleCancer gene therapy2025

APOE deficiency triggers anti-tumour activity of macrophages in liver cancer.

Xintong Xia, Zijun Zhou, Xiaoxiao Zheng, Chaoyong Tu, Hao Liu, Zhiming Hu, Tao Ma, Yuexiao Tang, Wei Chen

Abstract read
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Article in Cancer gene therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xintong Xia *College of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Zijun Zhou *College of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Xiaoxiao ZhengKey Laboratory of Cancer Prevention and Therapy Combining Traditional Chinese and Western Medicine of Zhejiang Province, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Chaoyong TuDepartment of Hepatobiliary and Pancreatic Surgery, Lishui Central Hospital, The Fifth Hospital Affiliated to Wenzhou Medical University, Lishui, China.
Hao LiuKey Laboratory of Cancer Prevention and Therapy Combining Traditional Chinese and Western Medicine of Zhejiang Province, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Zhiming HuDepartment of Hepatobiliary and Pancreatic Surgery, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Tao MaDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. zjumatao@gmail.com.
Yuexiao TangDepartment of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. tangyuexiao_11@163.com.
Wei ChenCollege of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China. wei_chen@zju.edu.cn.ORCID http://orcid.org/0000-0002-0399-6216

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82303369
6 · The paper itself

Abstract

Macrophage infiltration correlates with poor prognosis in patients with liver cancer and resistance to immunotherapy. However, it is difficult to target tumour-associated macrophages (TAMs) because of their inherent heterogeneity. Specific TAM subsets may exhibit distinct functions in tumorigenesis. Herein, we identify a TAM subset characterised by elevated APOE expression, which is correlated with poor overall survival of patients with HCC. The APOE

Indexed as

Apolipoproteins ECarcinoma, HepatocellularLiver NeoplasmsMacrophagesTumor-Associated MacrophagesAnimalsCD8-Positive T-LymphocytesCell Line, TumorDisease Models, AnimalFemaleHumansMaleMiceTumor MicroenvironmentApoE protein, humanApolipoproteins E

Identifiers

PMID40659861

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.