ArticleNature neuroscience2025
Direct interactions between the human insula and hippocampus during memory encoding.
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuroimaging evidence for central mechanisms of acupuncture in non-specific low back pain: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- An exploratoryEuropean journal of nuclear medicine and molecular imaging · 2026Article
- A Single OLED With Hybrid Synaptic Plasticity Enabling In Situ Neuromorphic Processing and Visualization.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Neural integrator and orchestrator communities shape spontaneous signaling in the human brain.PNAS nexus · 2026Article
- Phenotyping Overactive Bladder-Part 1: Are There Different Types of Urgency and Can They be Translated to Clinical, Urodynamic and Radiological Phenotyping? ICI-RS 2025.Neurourology and urodynamics · 2026Review
- Effective connectivity of the insula as measured by cortico-cortical evoked potentials.medRxiv : the preprint server for health sciences · 2026Article
- Neural integrator and orchestrator communities shape spontaneous signaling in the human brain.bioRxiv : the preprint server for biology · 2026Article
- Interaction of insula and hippocampus in memory dysfunction in Alzheimer's disease.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The hippocampus is critical for encoding episodic memories, but how it interacts with cortical regions during this process remains unclear. In this study, 16 participants with implanted electrodes in the insula (217 sites) and hippocampus (131 sites) viewed emotionally valenced words and attempted to recall them. During encoding, one subset of insular neuronal populations showed changes in aperiodic activity that predicted successful recall. These insular changes followed hippocampal theta but preceded hippocampal ripples. Another subset of insular sites responded to word valence, unrelated to memory performance. Direct electrical stimulation of memory-related insular sites evoked early responses in the ipsilateral hippocampus, whereas stimulation of valence-related sites did not. Conversely, stimulating hippocampal sites produced slow, variable signals across all insular sites, suggesting asymmetric communication between the hippocampus and the insula. These findings provide a glimpse of mesoscale hippocampal interactions with functionally selective neuronal populations within a given cortical structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.