Evidence map›Paper›PMID 40659844›Full record

ArticleNature neuroscience2025

An expanded subventricular zone supports postnatal cortical interneuron migration in gyrencephalic brains.

JaeYeon Kim, Aunoy Poddar, Kadellyn Sandoval, Julia Chu, Emma Horton, Di Cui, Keira Nakamura, I-Ling Lu, Michael Mui, Theresa Bartels and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

JaeYeon Kim *Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-0542-9071
Aunoy Poddar *Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-5065-7321
Kadellyn SandovalDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Julia ChuDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Emma HortonDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Di CuiDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Keira NakamuraDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0009-0009-8054-6049
I-Ling LuEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
Michael MuiDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1985-376X
Theresa BartelsDepartment of Paediatrics, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-4100-0608
Christian M WoodDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-1267-5032
Susana I RamosDepartment of Pathology, Molecular, and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID http://orcid.org/0000-0003-2886-6781
David H RowitchEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
Nadejda M TsankovaDepartment of Pathology, Molecular, and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID http://orcid.org/0009-0007-0943-3872
Hosung KimDepartment of Neurology, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-2269-8644
Chet C SherwoodDepartment of Anthropology Center for the Advanced Study of Human Paleobiology, The George Washington University, Washington, DC, USA.ORCID http://orcid.org/0000-0001-6711-449X
Boris W KramerDepartment of Neonatology, Poznan University of Medical Sciences, Poznan, Poland.
Angela C RobertsDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-2873-157X
Pablo J RossDepartment of Animal Science, University of California, Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0002-3972-3754
Duan XuDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Nicola J RobertsonInstitute for Women's Health, University College London, London, UK.ORCID http://orcid.org/0000-0002-5783-0828
Elizabeth A MagaDepartment of Animal Science, University of California, Davis, Davis, CA, USA.
Peng JiDepartment of Nutrition, University of California, Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0002-7447-5688
Mercedes F ParedesDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA. mercedes.paredes@ucsf.edu.ORCID http://orcid.org/0000-0003-2503-1447

Funding

Regulation of Cellular Pathwaysin Human Brain DevelopmentP01NS083513 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FANCY, STEPHEN PHILIP JAMES · 2014 to 2024
$12.6M
PREDOCTORAL TRAINING IN DEVELOPMENTAL BIOLOGYT32HD007470 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Todd Nystul · 1994 to 2026
$7.7M
Gyrencephalic Model for Neurodevelopmental Disease and Postnatal Cortical Therapeutic InterventionsDP2NS122550 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PAREDES, MERCEDES · 2020 to 2020
$2.4M
A National Chimpanzee Brain ResourceR24NS092988 · NINDS · GEORGE WASHINGTON UNIVERSITY · PI SHERWOOD, CHESTER · 2015 to 2018
$969k
Late-migrating interneurons in the postnatal brainK08NS091537 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PAREDES, MERCEDES · 2015 to 2019
$968k
NICHD NIH HHS T32 HD007470NINDS NIH HHS DP2 NS122550NINDS NIH HHS K08 NS091537NINDS NIH HHS P01 NS083513NINDS NIH HHS R24 NS092988U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS083513, NS122550-01Wellcome Trust
6 · The paper itself

Abstract

Cortical GABAergic interneurons generated in the ventral developing brain travel long distances to their final destinations. While there are examples of interneuron migration in the neonatal human brain, the extent of postnatal migration across species and how it contributes to cortical interneuron composition remains unknown. Here we demonstrate that neonatal gyrencephalic brains, including humans, nonhuman primates and piglets, harbor an elaborate subventricular zone, termed the Arc, due to its curved morphology and expanded neuroblast populations. The Arc is absent in lissencephalic marmoset and mouse brains. Transcriptomic and histological approaches revealed that Arc neurons are diverse interneurons from the medial and caudal ganglionic eminences that migrate into the frontal, cingulate and temporal cortex. Arc-cortical targets exhibit an increase in VIP

Indexed as

Cell MovementCerebral CortexInterneuronsAnimalsAnimals, NewbornCallithrixFemaleHumansLateral VentriclesMaleMiceMice, Inbred C57BLNeurogenesisSwine

Identifiers

PMID40659844
PMCPMC12321571

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.